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TRPC

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7).

Products
Background
Literature (1)
Gene Data

Modulators
Cat. No. Product Name / Activity
6875 TRPC6-PAM-C20
Selective TRPC6 positive allosteric modulator

Inhibitors
Cat. No. Product Name / Activity
6495 AM 12
TRPC5 inhibitor
6494 Galangin
TRPC5 inhibitor; also induces autophagy
7170 D-GsMTx4
TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
5831 SAR 7334
Potent TRPC6 inhibitor

Activators
Cat. No. Product Name / Activity
6940 BTD
Selective TRPC5 activator
4522 Flufenamic acid
Activates TRPC6; NSAID
6508 GSK 1702934A
Potent and selective TRPC3/6 activator
0768 Riluzole hydrochloride
TRPC5 activator; also inhibits GABA uptake and glutamate release and blocks NaV channels

Blockers
Cat. No. Product Name / Activity
6766 AC 1903
Selective TRPC5 blocker
4912 GsMTx4
TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels
5807 M 084 hydrochloride
TRPC4/5 channel blocker; antidepressant and anxiolytic
4732 ML 204
Selective TRPC4 blocker
3751 Pyr3
Selective TRPC3 blocker
1147 SKF 96365 hydrochloride
TRPC channel blocker; also inhibits store-operated Ca2+ entry

Other
Cat. No. Product Name / Activity
7013 OptoBI-1
Photoswitchable TRPC3/6/7 agonist

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions varies between different members of the family. Generally, TRPC channels can be activated by phospholipase C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).

The function and regulation of heterologously expressed TRPC channels has been controversial; some evidence suggests that TRPC channels act as store-operated channels, activated by depletion of intracellular calcium. Whereas, there is some conflicting data suggesting they can act as receptor-operated channels, insensitive to store depletion.

External sources of pharmacological information for TRPC :

Literature for TRPC

Tocris offers the following scientific literature for TRPC to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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TRPC Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TRPC, member 1 Human TRPC1 NM_003304 P48995
Mouse Trpc1 NM_011643 NP_035773
Rat Trpc1 NM_053558 NP_446010
TRPC, member 3 Human TRPC3 NM_003305 Q13507
Mouse Trpc3 NM_019510 NP_062383
Rat Trpc3 NM_021771 NP_068539
TRPC, member 4 Human TRPC4 NM_003306 Q9UBN4
Mouse Trpc4 NM_016984 NP_058680
Rat Trpc4 NM_001083115 NP_001076584
TRPC, member 5 Human TRPC5 NM_012471 Q9UL62
Mouse Trpc5 NM_009428 NP_033454
Rat Trpc5 NM_080898 NP_543174
TRPC, member 6 Human TRPC6 NM_004621 Q9Y210
Mouse Trpc6 NM_013838 NP_038866
Rat Trpc6 NM_053559 NP_446011
TRPC, member 7 Human TRPC7 NM_020389 Q9HCX4
Mouse Trpc7 NM_012035 NP_036165
Rat Trpc7 NM_001191691 NP_001178620