TRPC

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions varies between different members of the family. Generally, TRPC channels can be activated by phospholipase C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).

The function and regulation of heterologously expressed TRPC channels has been controversial; some evidence suggests that TRPC channels act as store-operated channels, activated by depletion of intracellular calcium. Whereas, there is some conflicting data suggesting they can act as receptor-operated channels, insensitive to store depletion.

External sources of pharmacological information for TRPC :

• IUPHAR Receptor Code

• BJP Guide

Literature for TRPC

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TRPC Gene Data