The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein (TRPC1-7).
Modulators |
Cat. No. | Product Name / Activity |
---|---|
6875 | TRPC6-PAM-C20 |
Selective TRPC6 positive allosteric modulator | |
Inhibitors |
Cat. No. | Product Name / Activity |
6495 | AM 12 |
TRPC5 inhibitor | |
6494 | Galangin |
TRPC5 inhibitor; also induces autophagy | |
7170 | D-GsMTx4 New |
TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion | |
5831 | SAR 7334 |
Potent TRPC6 inhibitor | |
Activators |
Cat. No. | Product Name / Activity |
6940 | BTD |
Selective TRPC5 activator | |
4522 | Flufenamic acid |
Activates TRPC6; NSAID | |
6508 | GSK 1702934A |
Potent and selective TRPC3/6 activator | |
0768 | Riluzole hydrochloride |
TRPC5 activator; also inhibits GABA uptake and glutamate release and blocks NaV channels | |
Blockers |
Cat. No. | Product Name / Activity |
6766 | AC 1903 |
Selective TRPC5 blocker | |
4912 | GsMTx4 |
TRPC1 and TRPC6 blocker; inhibits mechanosensitive ion channels | |
5807 | M 084 hydrochloride |
TRPC4/5 channel blocker; antidepressant and anxiolytic | |
4732 | ML 204 |
Selective TRPC4 blocker | |
3751 | Pyr3 |
Selective TRPC3 blocker | |
1147 | SKF 96365 hydrochloride |
TRPC channel blocker; also inhibits store-operated Ca2+ entry | |
Other |
Cat. No. | Product Name / Activity |
7013 | OptoBI-1 |
Photoswitchable TRPC3/6/7 agonist |
The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions varies between different members of the family. Generally, TRPC channels can be activated by phospholipase C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).
The function and regulation of heterologously expressed TRPC channels has been controversial; some evidence suggests that TRPC channels act as store-operated channels, activated by depletion of intracellular calcium. Whereas, there is some conflicting data suggesting they can act as receptor-operated channels, insensitive to store depletion.
Tocris offers the following scientific literature for TRPC to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
TRPC, member 1 | Human | TRPC1 | NM_003304 | P48995 |
Mouse | Trpc1 | NM_011643 | NP_035773 | |
Rat | Trpc1 | NM_053558 | NP_446010 | |
TRPC, member 3 | Human | TRPC3 | NM_003305 | Q13507 |
Mouse | Trpc3 | NM_019510 | NP_062383 | |
Rat | Trpc3 | NM_021771 | NP_068539 | TRPC, member 4 | Human | TRPC4 | NM_003306 | Q9UBN4 |
Mouse | Trpc4 | NM_016984 | NP_058680 | |
Rat | Trpc4 | NM_001083115 | NP_001076584 | |
TRPC, member 5 | Human | TRPC5 | NM_012471 | Q9UL62 |
Mouse | Trpc5 | NM_009428 | NP_033454 | |
Rat | Trpc5 | NM_080898 | NP_543174 | |
TRPC, member 6 | Human | TRPC6 | NM_004621 | Q9Y210 |
Mouse | Trpc6 | NM_013838 | NP_038866 | |
Rat | Trpc6 | NM_053559 | NP_446011 | |
TRPC, member 7 | Human | TRPC7 | NM_020389 | Q9HCX4 |
Mouse | Trpc7 | NM_012035 | NP_036165 | |
Rat | Trpc7 | NM_001191691 | NP_001178620 |