SKF 96365 hydrochloride

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Cat.No. 1147 - SKF 96365 hydrochloride | C22H26N2O3.HCl | CAS No. 130495-35-1
Description: TRPC channel blocker; also inhibits store-operated Ca2+ entry
Chemical Name: 1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl-1H-imidazole hydrochloride
Purity: ≥99% (HPLC)
Citations (14)
Reviews (1)
Literature (1)

Biological Activity

Store-operated Ca2+ entry (SOCE) inhibitor that inhibits STIM1. Also blocks TRPC channels, voltage-gated Ca2+ channels and potassium channels.

Technical Data

M. Wt 402.92
Formula C22H26N2O3.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 130495-35-1
PubChem ID 104955

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 8.06 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 402.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12.41 mL 62.05 mL 124.09 mL
1 mM 2.48 mL 12.41 mL 24.82 mL
2 mM 1.24 mL 6.2 mL 12.41 mL
10 mM 0.25 mL 1.24 mL 2.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Merritt et al (1990) SK&F96365, a novel inhibitor of receptor-mediated calcium entry. Biochem.J. 271 515 PMID: 2173565

Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118 PMID: 19187978

Singh et al (2010) The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br.J.Pharmacol. 160 1464 PMID: 20590636

If you know of a relevant reference for SKF 96365 hydrochloride, please let us know.

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14 Citations for SKF 96365 hydrochloride

Citations are publications that use Tocris products. Selected citations for SKF 96365 hydrochloride include:

Sahu et al (2019) Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep 28 2567 PMID: 31484069

Kyriazis et al (2010) Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem 285 6811 PMID: 20038578

Fu and Pol (2010) Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci 30 10205 PMID: 20668204

Ben-Mabrouk and Tryba (2010) Substance P modulation of TRPC3/7 channels improves respiratory rhythm regularity and ICAN-dependent pacemaker activity. Mol Pain 31 1219 PMID: 20345918

Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551 PMID: 15140926

Szikra et al (2009) Calcium homeostasis and cone signaling are regulated by interactions between calcium stores and plasma membrane ion channels. PLoS One 4 e6723 PMID: 19696927

Hildebrand et al (2009) Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci 29 9668 PMID: 19657020

Moneer et al (2003) Nitric oxide co-ordinates the activities of the capacitative and non-capacitative Ca2+-entry pathways regulated by vasopressin. Eur J Neurosci 370 439 PMID: 12459038

Lim et al (2001) NAADP+ initiates the Ca2+ response during fertilization of starfish oocytes. FASEB J 15 2257 PMID: 11641253

Alkhani et al (2014) Contribution of TRPC3 to store-operated calcium entry and inflammatory transductions in primary nociceptors. Proc Natl Acad Sci U S A 10 43 PMID: 24965271

Soltoff and Lannon (2013) Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells. PLoS One 8 e72881 PMID: 24009711

Kubota et al (2014) mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS One 9 e106316 PMID: 25181481

Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. Biochem J 33 11361 PMID: 23843509

Shin et al (2008) Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. J Neuroinflammation 105 746 PMID: 18174329

Do you know of a great paper that uses SKF 96365 hydrochloride from Tocris? Please let us know.

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a Store-operated channel blocker.
By Anonymous on 05/02/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: microglia

SKF96365 at 20 microM blocks intracellular calcium influx through a store-operated channel in microglia culture.

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