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Transient receptor potential (TRP) channels are a superfamily of cation channels that are currently divided into six families. TRP channels are expressed ubiquitously and are activated by a wide range of stimuli.
TRP subunits assemble into homo- or heterotetramers with varied permeation properties. They are often functionally associated with G-protein-coupled receptors, receptor tyrosine kinases and phospholipase C and are regulated by the multipotent phosphatidylinositol pathway. Since TRPs are intimately linked with intracellular Ca2+ signaling, they are implicated in the control of cell cycle progression, cell migration, apoptosis and epithelial uptake of divalent ions.
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.