CaM Kinase

Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition, which can be relieved by increases in Ca2+ levels.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
4483 A 484954
CaM kinase III (eEF-2 kinase) inhibitor
2457 Arcyriaflavin A
Potent CaM Kinase II and cdk4/cyclin D1 inhibitor. Antiviral agent (anti-HCMV)
1688 Autocamtide-2-related inhibitory peptide
Selective CaM kinase II inhibitor
5959 Autocamtide-2-related inhibitory peptide, myristoylated
CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide
5215 KN 93 phosphate
CaM kinase II inhibitor; water soluble version of KN 93 (Cat. No. 1278).
1277 KN-62
CaM kinase II inhibitor
1278 KN 93
CaM kinase II inhibitor; also K+ channel blocker (KV)
3439 NH 125
CaM kinase III (eEF-2 kinase) inhibitor
1551 STO-609 acetate
Selective CaM kinase kinase inhibitor

Calmodulin-dependent kinases (CaMK) are a family of serine/threonine kinases that mediate many of the second messenger effects of Ca2+. At basal Ca2+ levels, CaMKs are maintained in a dormant state through autoinhibition. Increases in Ca2+ levels allows calmodulin to relieve this autoinhibition and activate the kinase activity.

There are two main classes of CaMKs; mulitfunctional CaMKs (CaMKK, CaMKI, CaMKII and CaMKIV) which have multiple downstream targets and substrate-specific CaMKs (CaMKIII) which have only one known downstream target. All CaMKs, with the exception of CaMKII, exist as monomers and most are expressed ubiquitously. Some subtypes display specific distributions, for example, CaMKIVβ is expressed exclusively in cerebellar granule cells. CaMKs have numerous cellular functions and they influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal re-organization and learning and memory.

External sources of pharmacological information for CaM Kinase :

    Literature for CaM Kinase

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    Calmodulin-Dependent Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    CaMKI Human CAMK1 NM_003656 Q14012
    Mouse Camk1 NM_133926 Q91YS8
    Rat Camk1 NM_134468 Q63450
    CaMKIδ Human CAMK1D NM_020397 Q8IU85
    Mouse Camk1d NM_177343 Q8BW96
    CaMKIγ Human CAMK1G NM_020439 Q96NX5
    Mouse Camk1g NM_144817 Q91VB2
    Rat Camk1g NM_182842 Q7TNJ7
    CaMKIIα Human CAMK2A NM_015981 Q9UQM7
    Mouse Camk2a NM_177407 P11798
    Rat Camk2a NM_012920 P11275
    CaMKIIβ Human CAMK2B NM_172084 Q9UNX7
    Mouse Camk2b NM_007595 P28652
    Rat Camk2b NM_021739 P08413
    CaMKIIδ Human CAMK2D NM_001221 Q13557
    Mouse Camk2d NM_001025439 Q6PHZ2
    Rat Camk2d NM_012519 P15791
    CaMKIIγ Human CaMK2G NM_172169 Q13555
    Mouse Camk2g NM_178597 Q923T9
    Rat Camk2g NM_133605 P70621
    CaMKIII Human EEF2K NM_013302 O00418
    Mouse Eef2k NM_007908 O08796
    Rat Eef2k NM_012947 P70531
    CaMKIV Human CAMK4 NM_001744 Q16566
    Mouse Camk4 NM_009793 P08414
    Rat Camk4 NM_012727 Q6LED8
    CaMKK1α Human CAMKK1 NM_032294 Q8N5S9
    Mouse Camkk1 NM_018883 Q8VBY2
    Rat Camkk1 NM_031662 P97756
    CaMKK2β Human CAMKK2 NM_172226 Q96RR4
    Mouse Camkk2 NM_145358 Q8C078
    Rat Camkk2 NM_031338 O88831