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Biological Activity for Pyr 10
Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.
Technical Data for Pyr 10
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Pyr 10
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Pyr 10
The following data is based on the product molecular weight 449.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.23 mL||11.13 mL||22.25 mL|
|5 mM||0.45 mL||2.23 mL||4.45 mL|
|10 mM||0.22 mL||1.11 mL||2.23 mL|
|50 mM||0.04 mL||0.22 mL||0.45 mL|
References for Pyr 10
References are publications that support the biological activity of the product.
Schleifer et al (2012) Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca2+ entry pathways. Br.J.Pharmacol. 167 1712 PMID: 22862290
Saliba et al (2019) Transient receptor potential canonical 3 and nuclear factor of activated T cells C3 signaling pathway critically regulates myocardial fibrosis. Antioxid.Redox.Signal. 30 1851 PMID: 30318928
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Citations for Pyr 10
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Reviews for Pyr 10
Average Rating: 4 (Based on 1 Review.)
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Used pyr to inhibit TRPC3 channel in PC12 cells. It can inhibit OAG induced TRPC3 current.