AC 1903

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Cat.No. 6766 - AC 1903 | C19H17N3O | CAS No. 831234-13-0
Description: Selective TRPC5 blocker
Chemical Name: N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective TRPC5 blocker (IC50 = 13.6 μM). Also displays weak inhibition at TRPC4 (IC50 >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Technical Data

M. Wt 303.36
Formula C19H17N3O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 831234-13-0
PubChem ID 667146
InChI Key OECUWHDVQIITIS-UHFFFAOYSA-N
Smiles C1(NCC2=CC=CO2)=NC3=CC=CC=C3N1CC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 303.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.59 mL 32.96 mL 65.93 mL
2.5 mM 1.32 mL 6.59 mL 13.19 mL
5 mM 0.66 mL 3.3 mL 6.59 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

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References

References are publications that support the biological activity of the product.

Chung et al (2017) TRP'ing up chronic kidney disease. Science 358 1256 PMID: 29217557

Zhou et al (2017) A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science 358 1332 PMID: 29217578

Minard et al (2018) Remarkable progress with small-molecule modulation of TRPC1/4/5 channels: implications for understanding the channels in health and disease. Cells 7 doi: 10.3390 PMID: 29865154


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