Flufenamic acid

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Cat.No. 4522 - Flufenamic acid | C14H10F3NO2 | CAS No. 530-78-9
Description: Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature
Pathways

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.

Technical Data

M. Wt 281.23
Formula C14H10F3NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 530-78-9
PubChem ID 3371
InChI Key LPEPZBJOKDYZAD-UHFFFAOYSA-N
Smiles O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.12 100
ethanol 28.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 281.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.56 mL 17.78 mL 35.56 mL
5 mM 0.71 mL 3.56 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.56 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

Tu et al (2009) Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J.Neurochem. 108 126 PMID: 19094061

Foster et al (2009) Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium 45 384 PMID: 19232718

Chi et al (2011) Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J.Pharmacol.Exp.Ther. 339 257 PMID: 21765041

White and Aylwin (1990) Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol.Pharmacol. 37 720 PMID: 1692608


If you know of a relevant reference for Flufenamic acid, please let us know.

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View all Calcium-activated Chloride Channel Blockers

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1 Citation for Flufenamic acid

Citations are publications that use Tocris products. Selected citations for Flufenamic acid include:

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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Pathways for Flufenamic acid

Apoptosis

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