Flufenamic acid

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Cat.No. 4522 - Flufenamic acid | C14H10F3NO2 | CAS No. 530-78-9
Description: Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.

Technical Data

M. Wt 281.23
Formula C14H10F3NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 530-78-9
PubChem ID 3371
InChI Key LPEPZBJOKDYZAD-UHFFFAOYSA-N
Smiles O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.12 100
ethanol 28.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 281.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.56 mL 17.78 mL 35.56 mL
5 mM 0.71 mL 3.56 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.56 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Tu et al (2009) Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J.Neurochem. 108 126 PMID: 19094061

Foster et al (2009) Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium 45 384 PMID: 19232718

Chi et al (2011) Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J.Pharmacol.Exp.Ther. 339 257 PMID: 21765041

White and Aylwin (1990) Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol.Pharmacol. 37 720 PMID: 1692608


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Citations for Flufenamic acid

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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
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  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
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Programmed Cell Death

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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Flufenamic acid

Apoptosis

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.

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