Flufenamic acid

Pricing Availability   Qty
Description: Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
Chemical Name: 2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid
Purity: ≥99% (HPLC)
Citations (3)
Reviews (1)
Literature (1)
Pathways (1)

Biological Activity for Flufenamic acid

Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.

Technical Data for Flufenamic acid

M. Wt 281.23
Formula C14H10F3NO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 530-78-9
PubChem ID 3371
Smiles O=C(C1=C(NC2=CC=CC(C(F)(F)F)=C2)C=CC=C1)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Flufenamic acid

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.12 100
ethanol 28.12 100

Preparing Stock Solutions for Flufenamic acid

The following data is based on the product molecular weight 281.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.56 mL 17.78 mL 35.56 mL
5 mM 0.71 mL 3.56 mL 7.11 mL
10 mM 0.36 mL 1.78 mL 3.56 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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Product Datasheets for Flufenamic acid

References for Flufenamic acid

References are publications that support the biological activity of the product.

Tu et al (2009) Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J.Neurochem. 108 126 PMID: 19094061

Foster et al (2009) Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium 45 384 PMID: 19232718

Chi et al (2011) Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J.Pharmacol.Exp.Ther. 339 257 PMID: 21765041

White and Aylwin (1990) Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol.Pharmacol. 37 720 PMID: 1692608

If you know of a relevant reference for Flufenamic acid, please let us know.

View Related Products by Product Action

View all Calcium-activated Chloride Channel Blockers

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3 Citations for Flufenamic acid

Citations are publications that use Tocris products. Selected citations for Flufenamic acid include:

O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations J Neurosci 40 4813 PMID: 32414784

Ute et al (2022) Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers. Exp Dermatol 31 1477-1499 PMID: 35913427

Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792

Do you know of a great paper that uses Flufenamic acid from Tocris? Please let us know.

Reviews for Flufenamic acid

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Flufenamic Acid interaction with AKR1C4 protein was measured.
By Anonymous on 08/26/2019
Species: Human

Flufenamic Acid interaction with AKR1C4 protein was measured. The activity relation pattern observed.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for Flufenamic acid

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.