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Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 281.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.56 mL||17.78 mL||35.56 mL|
|5 mM||0.71 mL||3.56 mL||7.11 mL|
|10 mM||0.36 mL||1.78 mL||3.56 mL|
|50 mM||0.07 mL||0.36 mL||0.71 mL|
References are publications that support the biological activity of the product.
Tu et al (2009) Diacylglycerol analogues activate second messenger-operated calcium channels exhibiting TRPC-like properties in cortical neurons. J.Neurochem. 108 126 PMID: 19094061
Foster et al (2009) Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells. Cell Calcium 45 384 PMID: 19232718
Chi et al (2011) Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase. J.Pharmacol.Exp.Ther. 339 257 PMID: 21765041
White and Aylwin (1990) Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol.Pharmacol. 37 720 PMID: 1692608
If you know of a relevant reference for Flufenamic acid, please let us know.
Keywords: Flufenamic acid, Flufenamic acid supplier, nsaids, antiinflammatories, antiinflammatory, Flufenamic, acid, activates, trpc6, agonists, Cyclooxygenase, TRPC, Ca2+-Activated, Chloride, Channels, 4522, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Flufenamic acid include:
O'Malley et al (2020) TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations J Neurosci 40 4813 PMID: 32414784
Sun et al (2014) Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel. Sci Rep 4 4934 PMID: 24816792
Do you know of a great paper that uses Flufenamic acid from Tocris? Please let us know.
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Flufenamic Acid interaction with AKR1C4 protein was measured. The activity relation pattern observed.
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