IP3 Receptors
Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.
IP3 Receptor Antagonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1224 | 2-APB |
| IP3 receptor antagonist. Also TRP channel modulator | |
IP3 Receptor Modulators |
|
| Cat. No. | Product Name / Activity |
| 7909 | ARN 11391 |
| Potentiator of the IP3-gated calcium channel ITPR1 | |
Other |
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| Cat. No. | Product Name / Activity |
| 6210 | ci-IP3/PM |
| Caged inositol triphosphate | |
| 1280 | (-)-Xestospongin C |
| Reported inhibitor of IP3-dependent Ca2+ release | |
Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.
IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.
External sources of pharmacological information for IP3 Receptors :
IP3 Receptor Gene Data
| Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
|---|---|---|---|---|
| IP3R1 | Human | ITPR1 | NM_002222 | Q14643 |
| Mouse | Itpr1 | NM_010585 | P11881 | |
| Rat | Itpr1 | NM_001007235 | Q5BJS8 | |
| IP3R2 | Human | ITPR2 | NM_002223 | Q14571 |
| Mouse | Itpr2 | NM_019923 | Q9Z329 | |
| Rat | Itpr2 | NM_031046 | Q6W3E4 | |
| IP3R3 | Human | ITPR3 | NM_002224 | Q14573 |
| Mouse | Itpr3 | NM_080553 | P70227 | |
| Rat | Itpr3 | NM_013138 | Q63269 |