IP3 Receptors

Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.

Products
Background
Gene Data

Antagonists

Cat No Product Name / Activity
1224 2-APB
IP3 receptor antagonist. Also TRP channel modulator

Other

Cat No Product Name / Activity
6210 ci-IP3/PM
Caged inositol triphosphate
1280 (-)-Xestospongin C
Reported inhibitor of IP3-dependent Ca2+ release

Inositol 1,4,5-trisphosphate (IP3) receptors are a form of ligand-gated ion channels that are activated by cytosolic Ca2+ and IP3. They are localized to intracellular membranes, such as the endoplasmic reticulum, and mediate the mobilization of intracellular Ca2+ stores.

IP3 receptors play an important role in intracellular Ca2+ signaling in a variety of cell types. There are three IP3 receptor subtypes; IP3R1, IP3R2 and IP3R3, which exist as homo- and heterotetramers. All subtypes are closely associated with calmodulin and FK506-binding protein and are modulated through phosphorylation by PKA, PKC, PKG and CaMKII.

External sources of pharmacological information for IP3 Receptors :

    IP3 Receptor Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    IP3R1 Human ITPR1 NM_002222 Q14643
    Mouse Itpr1 NM_010585 P11881
    Rat Itpr1 NM_001007235 Q5BJS8
    IP3R2 Human ITPR2 NM_002223 Q14571
    Mouse Itpr2 NM_019923 Q9Z329
    Rat Itpr2 NM_031046 Q6W3E4
    IP3R3 Human ITPR3 NM_002224 Q14573
    Mouse Itpr3 NM_080553 P70227
    Rat Itpr3 NM_013138 Q63269