D-GsMTx4

Pricing Availability   Qty
Cat.No. 7170 - D-GsMTx4 | D-Gly-D-Cys-D-Leu-D-Glu-D-Phe-D-Trp-D-Trp-D-Lys-D-Cys-D-Asn-D-Pro-D-Asn-D-Asp-D-Asp-D-Lys-D-Cys-D-Cys-D-Arg-D-Pro-D-Lys-D-Leu-D-Lys-D-Cys-D-Ser-D-Lys-D-Leu-D-Phe-D-Lys-D-Leu-D-Cys-D-Asn-D-Phe-D-Ser-D-Phe-NH2
Description: TRPC1/6 and Piezo2 inhibitor; resistant to proteolytic digestion
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.

Licensing Information

Sold under license from The Research Foundation of The State University of New York

Technical Data

M. Wt 4095.86
Formula C185H273N49O45S6
Sequence GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF

(Modifications: All aminoacids = D-aminoacids, Disulfide bridge: 2-17,9-23,16-30), Phe-34 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
InChI Key WVDNTWXIIKNMHY-CFGROZRMSA-N
Smiles O=C(N[C@H](CSSC[C@H](C(N[C@H](CCCNC(N)=N)C(N1[C@H](CCC1)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@@H]2CCCCN)=O)=O)=O)=O)=O)NC3=O)C(N[C@H](CC(C)C)C(N[C@H](CCC(O)=O)C(N[C@H](CC4=CC=CC=C4)C(N[C@H](CC5=CNC6=CC=CC=C56)C(N[C@H](CC7=CNC8=CC=CC=C78)C(N[C@H](CCCCN)C(N[C@H](CSSC[C@H](C(N[C@H](CO)C(N[C@H](CCCCN)C(N[C@H](CC(C)C)C(N[C@H](CC9=CC=CC=C9)C(N[C@H](CCCCN)C(N[C@@H]%10CC(C)C)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@H](CC(N)=O)C(N%11[C@H](CCC%11)C(N[C@H](CC(N)=O)C(N[C@H](CC(O)=O)C(N[C@H](CC(O)=O)C(N[C@H](CCCCN)C(N[C@@H]3CSSC[C@H](C(N[C@H](CC(N)=O)C(N[C@H](CC%12=CC=CC=C%12)C(N[C@H](CO)C(N[C@H](CC%13=CC=CC=C%13)C(N)=O)=O)=O)=O)=O)NC%10=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Bae et al (2011) The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4 Biochemistry 50 6295 PMID: 21696149

Alcaino et al (2017) Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4 Channels (Austin) 11 245 PMID: 28085630

Maneshi et al (2018) Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Sci. Rep. 8 14267 PMID: 30250223

Gnanasambandam et al (2017) GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels Biophys.J. 112 31 PMID: 28076814


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Keywords: D-GsMTx4, D-GsMTx4 supplier, TRPC, transient, receptor, potential, TRPC1, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors, venoms, piezo2, Piezo, Channels, 7170, Tocris Bioscience

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