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TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusion model. Resistant to proteolytic digestion.
Sold under license from The Research Foundation of The State University of New York
(Modifications: All aminoacids = D-aminoacids, Disulfide bridge: 2-17,9-23,16-30), Phe-34 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Bae et al (2011) The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4 Biochemistry 50 6295 PMID: 21696149
Alcaino et al (2017) Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4 Channels (Austin) 11 245 PMID: 28085630
Maneshi et al (2018) Enantiomeric Aβ peptides inhibit the fluid shear stress response of PIEZO1 Sci. Rep. 8 14267 PMID: 30250223
Gnanasambandam et al (2017) GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels Biophys.J. 112 31 PMID: 28076814
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Keywords: D-GsMTx4, D-GsMTx4 supplier, TRPC, transient, receptor, potential, TRPC1, TRPC6, mechanosensitive, ion, channels, MSCs, blockers, blocks, inhibits, inhibitors, venoms, piezo2, Piezo, Channels, 7170, Tocris Bioscience
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