You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for SAR 7334
SAR 7334 is a potent TRPC6 inhibitor (IC50 values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca2+ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.
Technical Data for SAR 7334
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SAR 7334
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SAR 7334
The following data is based on the product molecular weight 440.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.27 mL||11.34 mL||22.69 mL|
|5 mM||0.45 mL||2.27 mL||4.54 mL|
|10 mM||0.23 mL||1.13 mL||2.27 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References for SAR 7334
References are publications that support the biological activity of the product.
Maier et al (2015) Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br.J.Pharmacol. 172 3650 PMID: 25847402
If you know of a relevant reference for SAR 7334, please let us know.
View Related Products by Product Action
Keywords: SAR 7334, SAR 7334 supplier, SAR7334, potent, transient, receptor, potential, canonical, channel, TRPC6, inhibitors, inhibits, orally, bioavailable, hypoxic, pulmonary, vasoconstriction, hpv, TRPC, 5831, Tocris Bioscience
4 Citations for SAR 7334
Citations are publications that use Tocris products. Selected citations for SAR 7334 include:
Gertjan et al (2021) Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol 19 e3001070 PMID: 33481771
Xiaoqiang et al (2019) The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells. FASEB J 33 6526-6538 PMID: 30785766
Vladislav et al (2020) Role of opioid signaling in kidney damage during the development of salt-induced hypertension. Life Sci Alliance 3 PMID: 33046522
Orie T et al (2020) Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. Curr Biol 30 2225-2237.e5 PMID: 32386535
Do you know of a great paper that uses SAR 7334 from Tocris? Please let us know.
Reviews for SAR 7334
There are currently no reviews for this product. Be the first to review SAR 7334 and earn rewards!
Have you used SAR 7334?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image