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Biological Activity for SAR 7334
SAR 7334 is a potent TRPC6 inhibitor (IC50 values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca2+ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.
Technical Data for SAR 7334
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SAR 7334
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SAR 7334
The following data is based on the product molecular weight 440.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.27 mL||11.34 mL||22.69 mL|
|5 mM||0.45 mL||2.27 mL||4.54 mL|
|10 mM||0.23 mL||1.13 mL||2.27 mL|
|50 mM||0.05 mL||0.23 mL||0.45 mL|
References for SAR 7334
References are publications that support the biological activity of the product.
Maier et al (2015) Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br.J.Pharmacol. 172 3650 PMID: 25847402
If you know of a relevant reference for SAR 7334, please let us know.
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Keywords: SAR 7334, SAR 7334 supplier, SAR7334, potent, transient, receptor, potential, canonical, channel, TRPC6, inhibitors, inhibits, orally, bioavailable, hypoxic, pulmonary, vasoconstriction, hpv, TRPC, 5831, Tocris Bioscience
Citations for SAR 7334
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