SAR 7334

Pricing Availability   Qty
Description: Potent TRPC6 inhibitor
Chemical Name: 4-[[(1R,2R)-2-[(3R)-3-Amino-1-piperidinyl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chlorobenzonitrile dihydrochloride
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for SAR 7334

SAR 7334 is a potent TRPC6 inhibitor (IC50 values are 9.5, 226 and 282 nM for TRPC6, TRPC7 and TRPC3-mediated Ca2+ influx). Exhibits no significant activity at TRPC4 and TRPC5 channels. Suppresses TRPC6-dependent acute hypoxic pulmonary vasoconstriction (HPV) in the isolated perfused mouse lung. Orally bioavailable.

Technical Data for SAR 7334

M. Wt 440.79
Formula C21H22ClN3O.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1333207-63-8
PubChem ID 78357800
Smiles N[C@@H]1CCCN([C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(C=C(C#N)C=C4)Cl)C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SAR 7334

Solvent Max Conc. mg/mL Max Conc. mM
water 44.08 100
DMSO 44.08 100

Preparing Stock Solutions for SAR 7334

The following data is based on the product molecular weight 440.79. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.27 mL 11.34 mL 22.69 mL
5 mM 0.45 mL 2.27 mL 4.54 mL
10 mM 0.23 mL 1.13 mL 2.27 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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References for SAR 7334

References are publications that support the biological activity of the product.

Maier et al (2015) Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br.J.Pharmacol. 172 3650 PMID: 25847402

If you know of a relevant reference for SAR 7334, please let us know.

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Keywords: SAR 7334, SAR 7334 supplier, SAR7334, potent, transient, receptor, potential, canonical, channel, TRPC6, inhibitors, inhibits, orally, bioavailable, hypoxic, pulmonary, vasoconstriction, hpv, TRPC, 5831, Tocris Bioscience

4 Citations for SAR 7334

Citations are publications that use Tocris products. Selected citations for SAR 7334 include:

Xiaoqiang et al (2019) The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells. FASEB J 33 6526-6538 PMID: 30785766

Vladislav et al (2020) Role of opioid signaling in kidney damage during the development of salt-induced hypertension. Life Sci Alliance 3 PMID: 33046522

Orie T et al (2020) Sites of Circadian Clock Neuron Plasticity Mediate Sensory Integration and Entrainment. Curr Biol 30 2225-2237.e5 PMID: 32386535

Gertjan et al (2021) Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol 19 e3001070 PMID: 33481771

Do you know of a great paper that uses SAR 7334 from Tocris? Please let us know.

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