BTD

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Cat.No. 6940 - BTD | C24H33N3O4S | CAS No. 896684-04-1
Description: Selective TRPC5 activator
Chemical Name: 6-Methyl-N-[3-(tricyclo[3.3.1.13,7]dec-1-yloxy)propyl]-4H-1,2,4-benzothiadiazine-3-propanamide-1,1-dioxide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Selective TRPC5 activator (EC50 = 1.4 μM in a calcium influx assay, 1.3 μM in whole cell patch clamp assay). Displays >14.5-fold selectivity for TRPC5 over other TRP channels (EC50 = 20.6 μM for TRPM8). Also activates TRPC1:5 and TRPC4:5 heteromers.

Technical Data

M. Wt 459.61
Formula C24H33N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 896684-04-1
PubChem ID 46369355
InChI Key YXADKMPRWFBOHW-UHFFFAOYSA-N
Smiles CC1=CC=C2C(NC(CCC(=O)NCCCOC34CC5CC(CC(C5)C3)C4)=N[S]2(=O)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 45.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 459.61. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.88 mL 21.76 mL
5 mM 0.44 mL 2.18 mL 4.35 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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References

References are publications that support the biological activity of the product.

Beckmann et al (2017) A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium. 66 10 PMID: 28807145


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Keywords: BTD, BTD supplier, selective, TRPC5, activators, transient, receptor, potental, channel, 5, activates, TRPC, 6940, Tocris Bioscience

Citations for BTD

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Literature in this Area

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