Phospholipase C

Phospholipase C (PLC) represents a group of enzymes that catalyze the hydrolysis of PIP2 (phosphatidylinositol 4,5-bisphosphate) to IP3 (inositol 1,4,5-trisphosphate) and DAG (1,2-diacylglycerol). IP3 and DAG both have important second messenger functions.

Products
Background
Gene Data

Inhibitors

Cat No Product Name / Activity
1437 D609
Selective PC-PLC inhibitor
3022 Edelfosine
Selective PI-PLC inhibitor, also PAF receptor agonist
1842 RHC 80267
Weak inhibitor of PLC and PLA2. Also diacylglycerol lipase inhibitor
1268 U 73122
Phospholipase C inhibitor
4133 U 73343
Analog of U 73122 (Cat. No. 1268)

Activators

Cat No Product Name / Activity
1941 m-3M3FBS
Phospholipase C activator
1942 o-3M3FBS
Inactive analog of m-3M3FBS (Cat. No. 1941)

Phospholipase C (PLC) (E.C. 3.1.4.11) represents a group of enzymes that catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions.

There are numerous subtypes of phospholipase C; PLCβ1-4, PLCγ1-2, PLCδ1-4, PLCε1, PLCζ1 and PLCη1-2, all which require Ca2+ ions for catalytic activity. PLC-β is primarily activated by Gq/11 proteins and PLC-γ is activated by tyrosine kinase-mediated phosphorylation in response to a variety of growth factor and immune system signals. PLCε represents a convergence of the 7-TM and receptor tyrosine kinase signaling pathways.

External sources of pharmacological information for Phospholipase C :

    Phospholipase C Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PLCβ1 Human PLCB1 NM_015192 Q9NQ65
    Mouse Plcb1 NM_019677 Q9Z1B3
    Rat Plcb1 NM_001077641 P10687
    PLCβ2 Human PLCB1 NM_004573 Q00722
    Mouse Plcb2 NM_177568 A3KGF7
    Rat Plcb2 NM_053478 O89040
    PLCβ3 Human PLCB3 NM_000932 Q01970
    Mouse Plcb3 NM_008874 P51432
    Rat Plcb3 NM_033350 Q45QJ4
    PLCβ4 Human PLCB4 NM_000933 Q9UJQ2
    Mouse Plcb4 NM_013829 NP_038857
    Rat Plcb4 NM_024353 Q9QW07
    PLCγ1 Human PLCG1 NM_182811 P19174
    Mouse Plcg1 NM_021280 Q62077
    Rat Plcg1 NM_013187 P10686
    PLCγ2 Human PLCG2 NM_002661 P16885
    Mouse Plcg2 NM_172285 Q8CIH5
    Rat Plcg2 NM_017168 P24135
    PLCδ1 Human PLCD1 NM_006225 P51178
    Mouse Plcd1 NM_019676 Q8R3B1
    Rat Plcd1 NM_017035 P10688
    PLCδ3 Human PLCD3 NM_133373 Q8N3E9
    Mouse Plcd3 NM_152813 Q8K2J0
    Rat Plcd3 NM_001105845 XP_221004
    PLCδ4 Human PLCD4 NM_032726 Q9BRC7
    Mouse Plcd4 NM_148937 Q8K3R3
    Rat Plcd4 NM_080688 Q62711
    PLCε1 Human PLCE1 NM_016341 Q9P212
    Mouse Plce1 NM_019588 Q8K4S1
    Rat Plce1 NM_053758 Q99P84
    PLCζ1 Human PLCZ1 NM_033123 Q86YW0
    Mouse Plcz1 NM_054066 Q8K4D7
    Rat Plcz1 NM_001012234 Q5FX52
    PLCη1 Human PLCH1 NM_014996 Q4KWH8
    Mouse Plch1 NM_183191 Q4KWH5
    Rat Plch1 XM_227208 XP_227208
    PLCη2 Human PLCH2 NM_014638 O75038
    Mouse Plch2 NM_175556 A2AP18
    Rat Plch2 XM_233728 XP_233728