ML 204

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Description: Selective TRPC4 inhibitor
Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity for ML 204

ML 204 is a blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Compound Libraries for ML 204

ML 204 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 204

M. Wt 226.32
Formula C15H18N2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 5465-86-1
PubChem ID 230710
Smiles CC2=CC(N3CCCCC3)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ML 204

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 22.63 100
1eq. HCl 5.66 25 with gentle warming

Preparing Stock Solutions for ML 204

The following data is based on the product molecular weight 226.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.09 mL 44.19 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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References for ML 204

References are publications that support the biological activity of the product.

Miller et al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program PMID: 22049577

Miller et al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436 PMID: 21795696

If you know of a relevant reference for ML 204, please let us know.

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Keywords: ML 204, ML 204 supplier, ML204, TRPC4, blockers, transient, receptor, potential, channels, canonical, TRPC, 4732, Tocris Bioscience

1 Citation for ML 204

Citations are publications that use Tocris products. Selected citations for ML 204 include:

Gertjan et al (2021) Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. PLoS Biol 19 e3001070 PMID: 33481771

Do you know of a great paper that uses ML 204 from Tocris? Please let us know.

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