ML 204

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Cat.No. 4732 - ML 204 | C15H18N2 | CAS No. 5465-86-1
Description: Selective TRPC4 blocker
Chemical Name: 4-Methyl-2-(1-piperidinyl)quinoline
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.

Technical Data

M. Wt 226.32
Formula C15H18N2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 5465-86-1
PubChem ID 230710
InChI Key USYRQXDHKXGTCK-UHFFFAOYSA-N
Smiles CC2=CC(N3CCCCC3)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 5.66 25mM with gentle warming
DMSO 22.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 226.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.42 mL 22.09 mL 44.19 mL
5 mM 0.88 mL 4.42 mL 8.84 mL
10 mM 0.44 mL 2.21 mL 4.42 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Miller et al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program PMID: 22049577

Miller et al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436 PMID: 21795696


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Keywords: ML204 TRPC4 blockers transient receptor potential channels canonical TRPC TRPC

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