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Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|1eq. HCl||5.66||25 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 226.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.42 mL||22.09 mL||44.19 mL|
|5 mM||0.88 mL||4.42 mL||8.84 mL|
|10 mM||0.44 mL||2.21 mL||4.42 mL|
|50 mM||0.09 mL||0.44 mL||0.88 mL|
References are publications that support the biological activity of the product.
Miller et al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program PMID: 22049577
Miller et al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436 PMID: 21795696
If you know of a relevant reference for ML 204, please let us know.
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Keywords: ML 204, ML 204 supplier, ML204, TRPC4, blockers, transient, receptor, potential, channels, canonical, TRPC, 4732, Tocris Bioscience
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