M 084 hydrochloride

Pricing Availability   Qty
Description: TRPC4 and TRPC5 inhibitor; antidepressant and anxiolytic
Chemical Name: N-Butyl-1H-benzimidazol-2-amine hydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for M 084 hydrochloride

M 084 hydrochloride is a TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.

Technical Data for M 084 hydrochloride

M. Wt 225.72
Formula C11H15N3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1992047-63-8
PubChem ID 121513894
Smiles CCCCNC1=NC2=CC=CC=C2N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for M 084 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 22.57 100
DMSO 22.57 100

Preparing Stock Solutions for M 084 hydrochloride

The following data is based on the product molecular weight 225.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.43 mL 22.15 mL 44.3 mL
5 mM 0.89 mL 4.43 mL 8.86 mL
10 mM 0.44 mL 2.22 mL 4.43 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets for M 084 hydrochloride

References for M 084 hydrochloride

References are publications that support the biological activity of the product.

Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID: 25816897

Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255 PMID: 26317356

If you know of a relevant reference for M 084 hydrochloride, please let us know.

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2 Citations for M 084 hydrochloride

Citations are publications that use Tocris products. Selected citations for M 084 hydrochloride include:

Cai and Ford (2018) DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate. Cell Rep 25 3148 PMID: 30540946

Melitta et al (2022) Interactions between the Polysialylated Neural Cell Adhesion Molecule and the Transient Receptor Potential Canonical Channels 1, 4, and 5 Induce Entry of Ca2+ into Neurons. Int J Mol Sci 23 PMID: 36077460

Do you know of a great paper that uses M 084 hydrochloride from Tocris? Please let us know.

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