M 084 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 5807 - M 084 hydrochloride | C11H15N3.HCl
Description: TRPC4/5 channel blocker; antidepressant and anxiolytic
Chemical Name: N-Butyl-1H-benzimidazol-2-amine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.

Technical Data

M. Wt 225.72
Formula C11H15N3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
PubChem ID 121513894
InChI Key DMLSYUAQEOLJQC-UHFFFAOYSA-N
Smiles CCCCNC1=NC2=CC=CC=C2N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.57 100
DMSO 22.57 100

Preparing Stock Solutions

The following data is based on the product molecular weight 225.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.43 mL 22.15 mL 44.3 mL
5 mM 0.89 mL 4.43 mL 8.86 mL
10 mM 0.44 mL 2.22 mL 4.43 mL
50 mM 0.09 mL 0.44 mL 0.89 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID: 25816897

Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255 PMID: 26317356


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Citations for M 084 hydrochloride

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