Calcium Binding Protein Modulators

Calcium binding proteins regulate the concentration of Ca2+ available as a second messenger in many signaling cascades. The most common calcium binding protein, calmodulin, is found in the cytoplasm, organelles or associated with plasma membranes in eukaryotic cells.

Products
Background
Gene Data

Agonists

Cat No Product Name / Activity
2090 CALP1
Cell-permeable calmodulin agonist
2321 CALP3
Cell-permeable calmodulin agonist

Antagonists

Cat No Product Name / Activity
0378 A-7 hydrochloride
Calmodulin antagonist
2561 Calmidazolium chloride
Calmodulin antagonist
2319 CALP2
Cell-permeable calmodulin antagonist
0953 Camstatin
Calmodulin antagonist
2255 CGS 9343B
Calmodulin antagonist
0361 W-13 hydrochloride
Calmodulin antagonist
0368 W-5 hydrochloride
Calmodulin antagonist
0369 W-7 hydrochloride
Calmodulin antagonist. Inhibits myosin light chain kinase
0370 W-9 hydrochloride
Calmodulin antagonist

Inhibitors

Cat No Product Name / Activity
2457 Arcyriaflavin A
Potent CaM Kinase II and cdk4/cyclin D1 inhibitor. Antiviral agent (anti-HCMV)
1688 Autocamtide-2-related inhibitory peptide
Selective CaM kinase II inhibitor
5959 Autocamtide-2-related inhibitory peptide, myristoylated
CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide
1277 KN-62
CaM kinase II inhibitor
1278 KN 93
CaM kinase II inhibitor; also K+ channel blocker (KV)
0431 ML 9 hydrochloride
Myosin light chain kinase inhibitor
1885 MLCK inhibitor peptide 18
Selective inhibitor of myosin light chain kinase
1551 STO-609 acetate
Selective CaM kinase kinase inhibitor

Other

Cat No Product Name / Activity
4130 KN 92
Inactive analog of KN 93. K+ channel (Kv) blocker

Calcium binding proteins act to regulate the concentration of Ca2+ available as a second messenger in a vast array of signaling cascades. The most common calcium binding protein is calmodulin. Calmodulin is expressed in all eukaryotic cells and can be found in the cytoplasm, within organelles or associated with the plasma membrane. Each calmodulin protein can bind four Ca2+ ions and functions to sequester Ca2+ ions, thus effecting intracellular signaling.

Ca2+/calmodulin-dependent protein kinases (CaMKs) are serine/threonine kinases that mediate many of the second messenger effects of Ca2+. They are activated by calmodulin and Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) in response to rises in intracellular Ca2+ levels. They influence processes as diverse as gene transcription, cell survival, apoptosis, cytoskeletal reorganization and learning and memory. Myosin light chain kinase (MLCK) is a specific CaMK involved in muscle contraction. MLCKs are activated by Ca2+-calmodulin complexes and require Ca2+ as a cofactor.

Calcium Binding Protein Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Calmoulin 1 Human CALM1 NM_006888 P62158
Mouse Calm1 AK162314 P62204
Rat Calm1 NM_031969 P62161
Calmodulin 2 Human CALM2 NM_001743 P62158
Mouse Calm2 AK002974 P62204
Rat Calm2 NM_017326 P62161
Calmodulin 3 Human CALM3 NM_005184 Q96HK3
Mouse Calm3 AK151610 P62204
Rat Calm3 NM_012518 P62161
CaMKI Human CAMK1 NM_003656 Q14012
Mouse Camk1 NM_133926 Q91YS8
Rat Camk1 NM_134468 Q63450
CaMKIδ Human CAMK1D NM_020397 Q8IU85
Mouse Camk1d NM_177343 Q8BW96
CaMKIγ Human CAMK1G NM_020439 Q96NX5
Mouse Camk1g NM_144817 Q91VB2
Rat Camk1g NM_182842 Q7TNJ7
CaMKIIα Human CAMK2A NM_015981 Q9UQM7
Mouse Camk2a NM_177407 P11798
Rat Camk2a NM_012920 P11275
CaMKIIβ Human CAMK2B NM_172084 Q9UNX7
Mouse Camk2b NM_007595 P28652
Rat Camk2b NM_021739 P08413
CaMKIIδ Human CAMK2D NM_001221 Q13557
Mouse Camk2d NM_001025439 Q6PHZ2
Rat Camk2d NM_012519 P15791
CaMKIIγ Human CaMK2G NM_172169 Q13555
Mouse Camk2g NM_178597 Q923T9
Rat Camk2g NM_133605 P70621
CaMKIII Human EEF2K NM_013302 O00418
Mouse Eef2k NM_007908 O08796
Rat Eef2k NM_012947 P70531
CaMKIV Human CAMK4 NM_001744 Q16566
Mouse Camk4 NM_009793 P08414
Rat Camk4 NM_012727 Q6LED8
CaMKK1α Human CAMKK1 NM_032294 Q8N5S9
Mouse Camkk1 NM_018883 Q8VBY2
Rat Camkk1 NM_031662 P97756
CaMKK2β Human CAMKK2 NM_172226 Q96RR4
Mouse Camkk2 NM_145358 Q8C078
Rat Camkk2 NM_031338 O88831
MLCK1 Human MYLK NM_053025 Q5MYA0
Mouse Mylk NM_139300 Q6PDN3
Rat Mylk NM_001105874 XP_213611
MLCK2 Human MYLK2 NM_033118 Q9H1R3
Mouse Mylk2 NM_001081044 Q8VCR8
Rat Mylk2 NM_057209 P20689
MLCK3 Human MYLK3 NM_182493 Q32MK0
Mouse Mylk3 NM_175441 Q3UIZ8
Rat Mylk3 NM_001110810 XP_214645
MLCK4 Human MYLK4 NM_001012418 Q86YV6