Akt (Protein Kinase B)

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane.

Products
Background
Literature
Pathways
Gene Data

Inhibitors

Cat No Product Name / Activity
5773 Akti-1/2
Potent and selective dual Akt1 and 2 inhibitor
3897 API-1
Selective Akt/PKB inhibitor. Antitumor
2151 API-2
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
2558 10-DEBC hydrochloride
Selective Akt/PKB inhibitor
2926 FPA 124
Akt/PKB inhibitor
4144 GSK 690693
Akt kinase inhibitor. Antitumor
6087 Perifosine
PKB/Akt inhibitor; also modulates Kv2.1 current
4598 PHT 427
Dual Akt and PDK1 inhibitor; antitumor
4398 SC 66
Allosteric Akt inhibitor

Substrates

Cat No Product Name / Activity
1353 Akt/SKG Substrate Peptide
Akt/PKB substrate (synthetic)
2422 AKTide-2T
Akt/PKB substrate (synthetic)

Activators

Cat No Product Name / Activity
4635 SC 79
Akt activator

Other

Cat No Product Name / Activity
5682 OSU 03012
Akt signaling inhibitor; inhibits PDPK1 (PDK1)

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, insulin signaling, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane via the PH (pleckstrin homology domain) of Akt.

Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478 (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2).

There are three isoforms of Akt: Akt 1, 2 and 3 (also known as PKBα, β and γ).

External sources of pharmacological information for Akt (Protein Kinase B) :

    Literature for Akt (Protein Kinase B)

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases
    Schizophrenia

    Schizophrenia Poster

    Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

    Pathways for Akt (Protein Kinase B)

    Akt

    Akt Signaling Pathway

    The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.

    Akt (Protein Kinase B) Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    AKT1 (PKBα) Human AKT1 NM_005163 P31749
    Mouse Akt1 NM_009652 P31750
    Rat Akt1 NM_033230 P47196
    AKT2 (PKBβ) Human AKT2 NM_001626 P31751
    Mouse Akt2 NM_001110208 Q60823
    Rat Akt2 NM_017093 P47197
    AKT3 (PKBγ) Human AKT3 NM_181690 Q9Y243
    Mouse Akt3 NM_011785 Q9WUA6
    Rat Akt3 NM_031575 Q63484