Akt (Protein Kinase B)

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane via the PH (pleckstrin homology domain) of Akt.

Akt is fully activated by phosphorylation at two key sites: Ser³⁰⁸ (phosphorylated by PDK1) and Thr⁴⁷⁸ (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2).

There are three isoforms of Akt: Akt 1, 2 and 3 (also known as PKBα, β and γ).

External sources of pharmacological information for Akt (Protein Kinase B) :

• IUPHAR Receptor Code

• BJP Guide

Literature for Akt (Protein Kinase B)

Tocris offers the following scientific literature for Akt (Protein Kinase B) to showcase our products. We invite you to request* your copy today!

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

• Cancer Metabolism
• Epigenetics in Cancer
• Receptor Signaling
• Cell Cycle and DNA Damage Repair
• Angiogenesis
• Invasion and Metastasis

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Pathways for Akt (Protein Kinase B)

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.

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Akt (Protein Kinase B) Gene Data