Akt (Protein Kinase B)

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane.

Products

Background

Pathways (1)

Gene Data

Akt (Protein Kinase B) Inhibitors
Cat. No.	Product Name / Activity
5773	Akti-1/2
	Potent and selective dual Akt1 and 2 inhibitor
2151	API-2
	Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
7001	AT 7867
	Potent pan-Akt and PKA inhibitor
6978	AZD 5363
	Potent pan-AKT inhibitor
2558	10-DEBC hydrochloride
	Selective Akt/PKB inhibitor
4144	GSK 690693
	Akt kinase inhibitor. Antitumor
7850	MK 2206 dihydrochloride
	Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
6087	Perifosine
	PKB/Akt inhibitor; also modulates K_v2.1 current
Akt (Protein Kinase B) Activators
Cat. No.	Product Name / Activity
4635	SC 79
	Akt activator
Degraders
Cat. No.	Product Name / Activity
8081	MS 143 New
	AKT kinase Degrader (PROTAC^®)
Other
Cat. No.	Product Name / Activity
5985	AKT Inhibitor IV
	Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
5682	OSU 03012
	Akt signaling inhibitor; inhibits PDPK1 (PDK1)
6762	Urolithin A
	PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Related Targets

Ack1

PI 3-Kinase/Akt Signaling

Akt is fully activated by phosphorylation at two key sites: Ser³⁰⁸ (phosphorylated by PDK1) and Thr⁴⁷⁸ (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2).

There are three isoforms of Akt: Akt 1, 2 and 3 (also known as PKBα, β and γ).

External sources of pharmacological information for Akt (Protein Kinase B) :

IUPHAR Receptor Code

BJP Guide

Pathways for Akt (Protein Kinase B)

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.