Akt (Protein Kinase B)

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane.

Products

Background

Literature (3)

Pathways (1)

Gene Data

Akt (Protein Kinase B) Inhibitors
Cat. No.	Product Name / Activity
5773	Akti-1/2
	Potent and selective dual Akt1 and 2 inhibitor
3897	API-1
	Selective Akt/PKB inhibitor. Antitumor
2151	API-2
	Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
7001	AT 7867
	Potent pan-Akt and PKA inhibitor
6978	AZD 5363
	Potent pan-AKT inhibitor
2558	10-DEBC hydrochloride
	Selective Akt/PKB inhibitor
2926	FPA 124
	Akt/PKB inhibitor
4144	GSK 690693
	Akt kinase inhibitor. Antitumor
7850	MK 2206 dihydrochloride New
	Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
6087	Perifosine
	PKB/Akt inhibitor; also modulates K_v2.1 current
4598	PHT 427
	Dual Akt and PDK1 inhibitor; antitumor
Akt (Protein Kinase B) Activators
Cat. No.	Product Name / Activity
4635	SC 79
	Akt activator
Other
Cat. No.	Product Name / Activity
5985	AKT Inhibitor IV
	Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
5682	OSU 03012
	Akt signaling inhibitor; inhibits PDPK1 (PDK1)
6762	Urolithin A
	PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Related Targets

Ack1

PI 3-Kinase/Akt Signaling

Akt is fully activated by phosphorylation at two key sites: Ser³⁰⁸ (phosphorylated by PDK1) and Thr⁴⁷⁸ (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2).

There are three isoforms of Akt: Akt 1, 2 and 3 (also known as PKBα, β and γ).

External sources of pharmacological information for Akt (Protein Kinase B) :

IUPHAR Receptor Code

BJP Guide

Literature for Akt (Protein Kinase B)

Tocris offers the following scientific literature for Akt (Protein Kinase B) to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

Cancer Metabolism
Epigenetics in Cancer
Receptor Signaling
Cell Cycle and DNA Damage Repair
Angiogenesis
Invasion and Metastasis

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

Receptor Tyrosine Kinases
Protein Kinases A, C, D and G
PI-3 Kinase, Akt and mTOR
MAPK Signaling
Receptor Serine/Threonine Kinases

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for Akt (Protein Kinase B)

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.