Akt (Protein Kinase B)

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane.

Products
Background
Pathways (1)
Gene Data

Akt (Protein Kinase B) Inhibitors

Cat. No. Product Name / Activity
5773 Akti-1/2
Potent and selective dual Akt1 and 2 inhibitor
3897 API-1
Selective Akt/PKB inhibitor. Antitumor
2151 API-2
Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
7001 AT 7867
Potent pan-Akt and PKA inhibitor
6978 AZD 5363
Potent pan-AKT inhibitor
2558 10-DEBC hydrochloride
Selective Akt/PKB inhibitor
2926 FPA 124
Akt/PKB inhibitor
4144 GSK 690693
Akt kinase inhibitor. Antitumor
7850 MK 2206 dihydrochloride
Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
6087 Perifosine
PKB/Akt inhibitor; also modulates Kv2.1 current

Akt (Protein Kinase B) Activators

Cat. No. Product Name / Activity
4635 SC 79
Akt activator

Other

Cat. No. Product Name / Activity
5985 AKT Inhibitor IV
Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
5682 OSU 03012
Akt signaling inhibitor; inhibits PDPK1 (PDK1)
6762 Urolithin A
PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Akt (Protein kinase B, PKB) is a serine/threonine kinase that plays a key in regulating cell survival, angiogenesis and tumor formation. Akt is a downstream mediator of the PI 3-K pathway, which results in the recruitment of Akt to the plasma membrane via the PH (pleckstrin homology domain) of Akt.

Akt is fully activated by phosphorylation at two key sites: Ser308 (phosphorylated by PDK1) and Thr478 (phosphorylated by mTOR and DNA-PK). Akt can then phosphorylated a wide range of substrates including transcription factors (e.g. FOXO1), kinases (GSK-3, Raf-1, ASK, Chk1) and other proteins with important signaling roles (e.g. Bad, MDM2).

There are three isoforms of Akt: Akt 1, 2 and 3 (also known as PKBα, β and γ).

External sources of pharmacological information for Akt (Protein Kinase B) :

Pathways for Akt (Protein Kinase B)

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.

Akt (Protein Kinase B) Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
AKT1 (PKBα) Human AKT1 NM_005163 P31749
Mouse Akt1 NM_009652 P31750
Rat Akt1 NM_033230 P47196
AKT2 (PKBβ) Human AKT2 NM_001626 P31751
Mouse Akt2 NM_001110208 Q60823
Rat Akt2 NM_017093 P47197
AKT3 (PKBγ) Human AKT3 NM_181690 Q9Y243
Mouse Akt3 NM_011785 Q9WUA6
Rat Akt3 NM_031575 Q63484