OSU 03012

Pricing Availability Delivery Time Qty
Cat.No. 5682 - OSU 03012 | C26H19F3N4O | CAS No. 742112-33-0
Description: PDPK1 (PDK1) inhibitor; inhibits Akt signaling
Chemical Name: 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide
Purity: ≥98% (HPLC)

Biological Activity

PDPK1 (PDK1) inhibitor; inhibits Akt signaling. Induces apoptosis of PC-3 and medulloblastoma cells, and inhibits growth of a number of tumor cell lines. Sensitizes radiotherapy-induced cell death and enhances cytotoxic effects of chemotherapeutic agents in vitro. Attenuates tumor growth of medulloblastoma xenografts in mice.

Compound Libraries

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Technical Data

M. Wt 460.45
Formula C26H19F3N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 742112-33-0
PubChem ID 10027278
Smiles O=C(CN)NC(C=C1)=CC=C1N2C(C(C=C3)=CC4=C3C5=CC=CC=C5C=C4)=CC(C(F)(F)F)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.05 100
ethanol 9.21 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 460.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.72 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Baryawno et al (2010) Small-molecule inhibitors of phosphatidylinositol 3-kinase/Akt signaling inhibit Wnt/β-catenin pathway cross-talk and suppress medulloblastoma growth. Cancer Res. 70 266 PMID: 20028853

Yacoub et al (2006) OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Mol.Pharmacol. 70 589 PMID: 16622074

Zhu et al (2004) From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer Res. 64 4309 PMID: 15205346

If you know of a relevant reference for OSU 03012, please let us know.

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Keywords: OSU 03012, supplier, OSU03012, PDK1, Akt, antitumor, anticancer, 3-phospho-inositide-dependent, kinases-1, PDPK1, Phosphoinositide-dependent, Kinase, 1, PDK1, Akt, (Protein, Kinase, B), Protein, Kinase, B/Akt, Phosphoinositide-dependent, Kinase, 1, Tocris Bioscience

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Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases