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Akti-1/2

Cat. No. 5773 Submit a Review Datasheet / COA / SDS
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Cat.No. 5773 - Akti-1/2 | C34N29N7O | CAS No. 612847-09-3
Description: Potent and selective dual Akt1 and 2 inhibitor
Chemical Name: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective dual Akt1 and 2 inhibitor (IC50 values are 50 and 210 nM, respectively). Selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. Sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Active in vivo.

Technical Data

M. Wt 551.64
Formula C34N29N7O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 612847-09-3
PubChem ID 10196499
InChI Key BIWGYFZAEWGBAL-UHFFFAOYSA-N
Smiles O=C1NC2=C(C=CC=C2)N1C(CC3)CCN3CC(C=C4)=CC=C4C5=NC6=CC(N=CN7)=C7C=C6N=C5C8=CC=CC=C8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.03 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 551.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 9.06 mL 45.32 mL 90.64 mL
1 mM 1.81 mL 9.06 mL 18.13 mL
2 mM 0.91 mL 4.53 mL 9.06 mL
10 mM 0.18 mL 0.91 mL 1.81 mL

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References

References are publications that support the biological activity of the product.

DeFeo-Jones D et al (2005) Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members. Mol.Cancer Ther. 4 271 PMID: 15713898

Barnett et al (2005) Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem. J. 385 399 PMID: 15456405

Lindsley et al (2005) Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg.Med.Chem.Lett. 15 761 PMID: 15664853

Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297 PMID: 17850214

If you know of a relevant reference for Akti-1/2, please let us know.

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Citations for Akti-1/2

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Literature in this Area

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Pathways for Akti-1/2

Akt

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.