DNA-Dependent Protein Kinase

DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage. DNA-PK is involved in the ligation step of the non-homologous end joining (NHEJ) pathway of DNA double strand break (DSB) repair.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3271 Compound 401
Selective DNA-PK and mTOR inhibitor
2088 DMNB
DNA-PK inhibitor
4702 ETP 45658
DNA-PK inhibitor; also inhibits PI 3-K and mTOR
4840 KU 0060648
Dual DNA-PK and PI 3-K inhibitor
5834 LTURM 34
Potent DNA-PK inhibitor
2828 NU 7026
Selective DNA-PK inhibitor
3712 NU 7441
Potent and selective DNA-PK inhibitor
2930 PI 103 hydrochloride
Inhibitor of DNA-PK, mTOR and PI 3-kinase

DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage. DNA-PK is involved in the ligation step of the non-homologous end joining (NHEJ) pathway of DNA double strand break (DSB) repair, V(D)J recombination and telomere stabilization.

DNA-PK is activated by phosphorylation by ATM/ATR following DNA damage and is inhibited by wortmannin. DNA-PK must be bound to DNA in order to exhibit its catalytic properties and has multiple targets including c-Abl, histone H1, c-jun, p53, c-Myc and more.

Literature for DNA-Dependent Protein Kinase

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

DNA-Dependent Protein Kinase Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human PRKDC NM_001081640 Q9UME3
Mouse Prkdc NM_011159 P97313