DNA-Dependent Protein Kinase

DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage. DNA-PK is involved in the ligation step of the non-homologous end joining (NHEJ) pathway of DNA double strand break (DSB) repair.

Products
Background
Literature (3)
Gene Data

Inhibitors

Cat. No. Product Name / Activity
3271 Compound 401
Selective DNA-PK and mTOR inhibitor
2088 DMNB
DNA-PK inhibitor
4702 ETP 45658
DNA-PK inhibitor; also inhibits PI 3-K and mTOR
4840 KU 0060648
Dual DNA-PK and PI 3-K inhibitor
5834 LTURM 34
Potent DNA-PK inhibitor
2828 NU 7026
Selective DNA-PK inhibitor
3712 NU 7441
Potent and selective DNA-PK inhibitor
6792 Omipalisib
Potent DNA-PK inhibitor; also inhibitor of mTOR and highly potent inhibitor of PI 3-kinase
2930 PI 103 hydrochloride
Inhibitor of DNA-PK, mTOR and PI 3-kinase

DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage. DNA-PK is involved in the ligation step of the non-homologous end joining (NHEJ) pathway of DNA double strand break (DSB) repair, V(D)J recombination and telomere stabilization.

DNA-PK is activated by phosphorylation by ATM/ATR following DNA damage and is inhibited by wortmannin. DNA-PK must be bound to DNA in order to exhibit its catalytic properties and has multiple targets including c-Abl, histone H1, c-jun, p53, c-Myc and more.

External sources of pharmacological information for DNA-Dependent Protein Kinase :

    Literature for DNA-Dependent Protein Kinase

    Tocris offers the following scientific literature for DNA-Dependent Protein Kinase to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases
    Cell Cycle & DNA Damage Repair

    Cell Cycle & DNA Damage Repair Poster

    In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

    DNA-Dependent Protein Kinase Gene Data

    Species Gene Symbol Gene Accession No. Protein Accession No.
    Human PRKDC NM_001081640 Q9UME3
    Mouse Prkdc NM_011159 P97313