DNA-Dependent Protein Kinase
DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage. DNA-PK is involved in the ligation step of the non-homologous end joining (NHEJ) pathway of DNA double strand break (DSB) repair.
DNA-Dependent Protein Kinase Inhibitors |
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|---|---|
| Cat. No. | Product Name / Activity |
| 4702 | ETP 45658 |
| DNA-PK inhibitor; also inhibits PI 3-K and mTOR | |
| 4840 | KU 0060648 |
| Dual DNA-PK and PI 3-K inhibitor | |
| 5834 | LTURM 34 |
| Potent DNA-PK inhibitor | |
| 2828 | NU 7026 |
| Selective DNA-PK inhibitor | |
| 3712 | NU 7441 |
| Potent and selective DNA-PK inhibitor | |
| 6792 | Omipalisib |
| Potent DNA-PK inhibitor; also inhibitor of mTOR and highly potent inhibitor of PI 3-kinase | |
| 2930 | PI 103 hydrochloride |
| Inhibitor of DNA-PK, mTOR and PI 3-kinase | |
DNA-dependent protein kinase (DNA-PK) is a nuclear protein serine/threonine kinase that is a molecular sensor of DNA damage. DNA-PK is involved in the ligation step of the non-homologous end joining (NHEJ) pathway of DNA double strand break (DSB) repair, V(D)J recombination and telomere stabilization.
DNA-PK is activated by phosphorylation by ATM/ATR following DNA damage and is inhibited by wortmannin. DNA-PK must be bound to DNA in order to exhibit its catalytic properties and has multiple targets including c-Abl, histone H1, c-jun, p53, c-Myc and more.
External sources of pharmacological information for DNA-Dependent Protein Kinase :
Literature for DNA-Dependent Protein Kinase
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Kinases Product Listing
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Our Cancer Research Guide highlights over 750 products for cancer research.
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Our Kinase listing highlights over 400 products for kinase research.
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Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
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