Home / Pharmacology / Enzymes / Kinases / Raf Kinases

Raf Kinases

Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated.

Products
Background
Literature
Gene Data

Inhibitors
Cat No Product Name / Activity
4836 AZ 628
Potent Raf kinase inhibitor
4453 GDC 0879
Potent B-Raf inhibitor
1381 GW 5074
Potent, selective c-Raf1 kinase inhibitor
5260 KG 5
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
5036 ML 786 dihydrochloride
Potent Raf kinase inhibitor; orally bioavailable
6015 RAF 265
Raf kinase and VEGFR-2 inhibitor
2650 SB 590885
Potent B-Raf inhibitor
1321 ZM 336372
Potent, selective c-Raf inhibitor

Other
Cat No Product Name / Activity
5475 Kobe 0065
H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling

Related Targets

    Raf kinases, a family of three serine/threonine kinases, are part of the Ras-MAPK signaling cascade and phosphorylate MEK. Upon growth factor stimulation, Raf-1 (or c-Raf) is activated by GTP-bound Ras and recruited to the cell membrane. This activation process is tightly regulated by a number of factors including phosphatases (e.g. PP1, PP2A, PP5), kinases (e.g. Src, ERK, Akt, PKC) and proteins that bind directly to Raf-1 (e.g. RKIP, 14-3-3ζ, KSR, Hsp90).

    Raf-1 is also thought to be able to dimerize with wild type B-Raf in a Ras-dependent process. B-Raf is commonly mutated and thereby activated in many human cancers, the most frequent mutation being the V600E mutation of the kinase domain. Whilst wild type B-Raf and Raf-1 are strongly activated by growth factor signals via Ras and Src, a-Raf is only modestly activated and has low basal activity. All three isoforms of Raf are considered to be oncogenic.

    Literature for Raf Kinases

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Immunology

    Immunology Product Listing

    A collection of over 190 products for immunology research, the guide includes research tools for the study of:

    • Chemokine and Cytokine Signaling
    • Chemotaxis
    • Complement System
    • Immune Cell Signaling
    • Inflammation
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    Raf Kinase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    c-Raf/Raf1 Human RAF1 NM_002880 P04049
    Mouse Raf1 NM_007658 P48964
    Rat Raf1 NM_012639 P11345
    a-Raf Human ARAF NM_001654 P10398
    Mouse Araf NM_009703 P04627
    Rat Araf NM_022532 P14056
    b-Raf Human BRAF NM_004333 P15056
    Mouse Braf NM_139294 P28028
    Rat Braf AF352172 Q99MC6