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The PI 3-Kinase/Akt signaling pathway is involved in fundamental cellular processes including protein synthesis, proliferation and survival. PI 3-kinase is activated following ligand binding to a range of receptors such as integrin receptors, receptor tyrosine kinases, cytokine receptors and some 7-TM receptors.
PI 3-kinase promotes PIP3 formation, which translocates Akt to cell membranes and allows Akt activation through phosphorylation mediated by phosphoinositide dependent kinase 1 (PDK1). Akt mediates many of the downstream actions of PI 3-kinase, which include activation of mTOR and p70 S6K to promote protein synthesis, inhibition of Bad to attenuate the proapoptotic signal and regulation of neuronal functioning through interactions with GABAA receptors. Furthermore, Akt is a key regulator of insulin signaling and glucose metabolism.
Tocris offers the following scientific literature for PI 3-Kinase/Akt Signaling to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.