PI 3-Kinase/Akt Signaling

The PI 3-Kinase/Akt signaling pathway is involved in fundamental cellular processes including protein synthesis, proliferation and survival. PI 3-kinase is activated following ligand binding to a range of receptors such as integrin receptors, receptor tyrosine kinases, cytokine receptors and some 7-TM receptors.

Targets
Literature
Pathways

PI 3-kinase promotes PIP3 formation, which translocates Akt to cell membranes and allows Akt activation through phosphorylation mediated by phosphoinositide dependent kinase 1 (PDK1). Akt mediates many of the downstream actions of PI 3-kinase, which include activation of mTOR and p70 S6K to promote protein synthesis, inhibition of Bad to attenuate the proapoptotic signal and regulation of neuronal functioning through interactions with GABAA receptors. Furthermore, Akt is a key regulator of insulin signaling and glucose metabolism.

Literature for PI 3-Kinase/Akt Signaling

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Pathways for PI 3-Kinase/Akt Signaling

Akt

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.