Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSC 79
Description: Akt activator
Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Biological Activity for SC 79
SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
Technical Data for SC 79
| M. Wt | 364.78 |
| Formula | C17H17ClN2O5 |
| Storage | Store at -20°C |
| CAS Number | 305834-79-1 |
| PubChem ID | 2810830 |
| InChI Key | DXVKFBGVVRSOLI-UHFFFAOYSA-N |
| Smiles | NC2=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C1=CC(Cl)=CC=C1O2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SC 79
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.48 | 100 |
Preparing Stock Solutions for SC 79
The following data is based on the product molecular weight 364.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.74 mL | 13.71 mL | 27.41 mL |
| 5 mM | 0.55 mL | 2.74 mL | 5.48 mL |
| 10 mM | 0.27 mL | 1.37 mL | 2.74 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for SC 79
References for SC 79
References are publications that support the biological activity of the product.
Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581 PMID: 22689977
If you know of a relevant reference for SC 79, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SC 79, SC 79 supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant, (Protein, Kinase, B), Protein, B/Akt, 4635, Tocris Bioscience
11 Citations for SC 79
Citations are publications that use Tocris products. Selected citations for SC 79 include:
Sladitschek and Neveu (2015) The bimodally expressed microRNA miR-142 gates exit from pluripotency. Sci Rep 11 850 PMID: 26690966
Moreira et al (2015) A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med 13 76 PMID: 25889299
Wang et al (2017) Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells. Stem Cell Res Ther 8 245 PMID: 29096702
Yutao et al (2021) FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti. Dev Dyn 250 134-144 PMID: 32735383
Wilson et al (2016) SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep 6 17735 PMID: 26787558
Peter et al (2019) GIV/Girdin promotes cell survival during endoplasmic reticulum stress. Mol Cell Biochem 453 79-88 PMID: 30145643
Lucie et al (2022) Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication. Viruses 14 PMID: 36146824
Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33060198
Andrii et al (2020) Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke. Biomaterials 227 119556 PMID: 31670035
Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33453946
Bei et al (2016) miR-382 targeting PTEN-Akt axis promotes liver regeneration. Mol Syst Biol 7 1584 PMID: 26636539
Do you know of a great paper that uses SC 79 from Tocris? Please let us know.
Reviews for SC 79
There are currently no reviews for this product. Be the first to review SC 79 and earn rewards!
Have you used SC 79?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis
Pathways for SC 79
