SC 79

Cat. No. 4635 11 Citations Submit a Review Datasheet / COA / SDS

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Description: Akt activator

Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

Datasheet

Citations (11)

Reviews

Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SC 79

SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

Technical Data for SC 79

M. Wt	364.78
Formula	C₁₇H₁₇ClN₂O₅
Storage	Store at -20°C
CAS Number	305834-79-1
PubChem ID	2810830
InChI Key	DXVKFBGVVRSOLI-UHFFFAOYSA-N
Smiles	NC2=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C1=CC(Cl)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SC 79

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.48	100

Preparing Stock Solutions for SC 79

The following data is based on the product molecular weight 364.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.71 mL	27.41 mL
5 mM	0.55 mL	2.74 mL	5.48 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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Product Datasheets for SC 79

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for SC 79

References are publications that support the biological activity of the product.

Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581 PMID: 22689977

If you know of a relevant reference for SC 79, please let us know.

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Keywords: SC 79, SC 79 supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant, (Protein, Kinase, B), Protein, B/Akt, 4635, Tocris Bioscience

11 Citations for SC 79

Citations are publications that use Tocris products. Selected citations for SC 79 include:

Lucie et al (2022) Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication. Viruses 14 PMID: 36146824

Peter et al (2019) GIV/Girdin promotes cell survival during endoplasmic reticulum stress. Mol Cell Biochem 453 79-88 PMID: 30145643

Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33060198

Andrii et al (2020) Engineered antibody-functionalized porous silicon nanoparticles for therapeutic targeting of pro-survival pathway in endogenous neuroblasts after stroke. Biomaterials 227 119556 PMID: 31670035

Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33453946

Wilson et al (2016) SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep 6 17735 PMID: 26787558

Wang et al (2017) Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells. Stem Cell Res Ther 8 245 PMID: 29096702

Sladitschek and Neveu (2015) The bimodally expressed microRNA miR-142 gates exit from pluripotency. Sci Rep 11 850 PMID: 26690966

Yutao et al (2021) FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti. Dev Dyn 250 134-144 PMID: 32735383

Moreira et al (2015) A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med 13 76 PMID: 25889299

Bei et al (2016) miR-382 targeting PTEN-Akt axis promotes liver regeneration. Mol Syst Biol 7 1584 PMID: 26636539

Do you know of a great paper that uses SC 79 from Tocris? Please let us know.

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Pathways for SC 79

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.