SC 79

Pricing Availability   Qty
Description: Akt activator
Chemical Name: 2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Datasheet
Citations (11)
Reviews
Pathways (1)

Biological Activity for SC 79

SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

Technical Data for SC 79

M. Wt 364.78
Formula C17H17ClN2O5
Storage Store at -20°C
CAS Number 305834-79-1
PubChem ID 2810830
InChI Key DXVKFBGVVRSOLI-UHFFFAOYSA-N
Smiles NC2=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C1=CC(Cl)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SC 79

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.48 100

Preparing Stock Solutions for SC 79

The following data is based on the product molecular weight 364.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.71 mL 27.41 mL
5 mM 0.55 mL 2.74 mL 5.48 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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References for SC 79

References are publications that support the biological activity of the product.

Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581 PMID: 22689977


If you know of a relevant reference for SC 79, please let us know.

View Related Products by Product Action

View all Akt (Protein Kinase B) Activators

Keywords: SC 79, SC 79 supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant, (Protein, Kinase, B), Protein, B/Akt, 4635, Tocris Bioscience

11 Citations for SC 79

Citations are publications that use Tocris products. Selected citations for SC 79 include:

Sladitschek and Neveu (2015) The bimodally expressed microRNA miR-142 gates exit from pluripotency. Sci Rep 11 850 PMID: 26690966

Moreira et al (2015) A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med 13 76 PMID: 25889299

Yutao et al (2021) FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti. Dev Dyn 250 134-144 PMID: 32735383

Bei et al (2016) miR-382 targeting PTEN-Akt axis promotes liver regeneration. Mol Syst Biol 7 1584 PMID: 26636539


Do you know of a great paper that uses SC 79 from Tocris? Please let us know.

Reviews for SC 79

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Pathways for SC 79

Akt Signaling Pathway

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.