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SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 364.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.74 mL||13.71 mL||27.41 mL|
|5 mM||0.55 mL||2.74 mL||5.48 mL|
|10 mM||0.27 mL||1.37 mL||2.74 mL|
|50 mM||0.05 mL||0.27 mL||0.55 mL|
References are publications that support the biological activity of the product.
Jo et al (2012) Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc.Natl.Acad.Sci.USA 109 10581 PMID: 22689977
If you know of a relevant reference for SC 79, please let us know.
Keywords: SC 79, SC 79 supplier, SC79, Akt, protein, kinase, B, PKB, activators, activates, brain, penetrant, (Protein, Kinase, B), Protein, B/Akt, 4635, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for SC 79 include:
Wilson et al (2016) SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination. Sci Rep 6 17735 PMID: 26787558
Moreira et al (2015) A small molecule activator of AKT does not reduce ischemic injury of the rat heart. J Transl Med 13 76 PMID: 25889299
Bei et al (2016) miR-382 targeting PTEN-Akt axis promotes liver regeneration. Mol Syst Biol 7 1584 PMID: 26636539
Wang et al (2017) Using low-risk factors to generate non-integrated human induced pluripotent stem cells from urine-derived cells. Stem Cell Res Ther 8 245 PMID: 29096702
Sladitschek and Neveu (2015) The bimodally expressed microRNA miR-142 gates exit from pluripotency. Sci Rep 11 850 PMID: 26690966
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.