Terazosin hydrochloride

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Cat.No. 1506 - Terazosin hydrochloride | C19H25N5O4.HCl | CAS No. 63074-08-8
Description: α1 and α2B antagonist (α1 > α2B). Orally active
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

α1- and α2B-adrenoceptor antagonist (Ki values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo.

Technical Data

M. Wt 423.9
Formula C19H25N5O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 63074-08-8
PubChem ID 44383
InChI Key IWSWDOUXSCRCKW-UHFFFAOYSA-N
Smiles Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.2 50mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 423.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.8 mL 23.59 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kyncl (1986) Pharmacology of terazosin. Am.J.Med. 80 12 PMID: 2872801

Hancock et al (1995) Actions of terazosin and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 15 863 PMID: 8673721

Maruyama et al (1994) Comparison of displacemental potencies of terazosin enantiomers for α1-adrenoceptor subtypes. Biol.Pharm.Bull. 17 1126 PMID: 7820122


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1 Citation for Terazosin hydrochloride

Citations are publications that use Tocris products. Selected citations for Terazosin hydrochloride include:

Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037


Do you know of a great paper that uses Terazosin hydrochloride from Tocris? If so please let us know.

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Pathways for Terazosin hydrochloride

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