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Submit ReviewTerazosin hydrochloride
Description: α1 antagonist; PGK1 activator
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Terazosin hydrochloride
Terazosin hydrochloride is a selective α1 antagonist. Increases phosphoglycerate kinase 1 (PGK1) activity (Kd = 2.9 μM). Upregulates glucose metabolism and increases ATP production. In an in vitro model of GI disease, terazosin reduces inflammation and protects against oxidative damage. Neuroprotective in in vivo models of ALS and Parkinson's Disease. Antihypertensive following oral or intravenous administration in vivo.
Technical Data for Terazosin hydrochloride
| M. Wt | 423.9 |
| Formula | C19H25N5O4.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 63074-08-8 |
| PubChem ID | 44383 |
| InChI Key | IWSWDOUXSCRCKW-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Terazosin hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.48 | 20 with gentle warming |
Preparing Stock Solutions for Terazosin hydrochloride
The following data is based on the product molecular weight 423.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 11.8 mL | 58.98 mL | 117.95 mL |
| 1 mM | 2.36 mL | 11.8 mL | 23.59 mL |
| 2 mM | 1.18 mL | 5.9 mL | 11.8 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.36 mL |
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Product Datasheets for Terazosin hydrochloride
References for Terazosin hydrochloride
References are publications that support the biological activity of the product.
Kyncl (1986) Pharmacology of tera. Am.J.Med. 80 12 PMID: 2872801
Hancock et al (1995) Actions of tera. and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 15 863 PMID: 8673721
Maruyama et al (1994) Comparison of displacemental potencies of tera. enantiomers for α1-adrenoceptor subtypes. Biol.Pharm.Bull. 17 1126 PMID: 7820122
If you know of a relevant reference for Terazosin hydrochloride, please let us know.
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Keywords: Terazosin hydrochloride, Terazosin hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, antagonists, Orally, active, Receptors, ALS, Parkinsons, ATP, production, PGK1, phosphoglycerate, kinase, 1antiinflammatory, neuroprotective, antihypertensive, Adrenergic, Alpha-1, Other, Kinases, 1506, Tocris Bioscience
2 Citations for Terazosin hydrochloride
Citations are publications that use Tocris products. Selected citations for Terazosin hydrochloride include:
Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566
Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037
Do you know of a great paper that uses Terazosin hydrochloride from Tocris? Please let us know.
Reviews for Terazosin hydrochloride
Average Rating: 5 (Based on 1 Review.)
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Used to investigate cell metabolism.
By
Anonymous on 12/22/2022
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Primary hippocampal neurons
The drug was incubated at 10 μM to investigate an effect on cell metabolism.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.