Terazosin hydrochloride

Pricing Availability   Qty
Description: α1 and α2B antagonist (α1 > α2B). Orally active
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-piperazine hydrochloride
Purity: ≥99% (HPLC)
Citations (2)
Reviews (1)
Literature (1)

Biological Activity for Terazosin hydrochloride

Terazosin hydrochloride is a α1- and α2B-adrenoceptor antagonist (Ki values are 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively). Antihypertensive following oral or intravenous administration in vivo.

Technical Data for Terazosin hydrochloride

M. Wt 423.9
Formula C19H25N5O4.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 63074-08-8
PubChem ID 44383
Smiles Cl.COC1=C(OC)C=C2C(N)=NC(=NC2=C1)N1CCN(CC1)C(=O)C1CCCO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Terazosin hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 21.2 50 with gentle warming

Preparing Stock Solutions for Terazosin hydrochloride

The following data is based on the product molecular weight 423.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.72 mL 23.59 mL 47.18 mL
2.5 mM 0.94 mL 4.72 mL 9.44 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

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Product Datasheets for Terazosin hydrochloride

References for Terazosin hydrochloride

References are publications that support the biological activity of the product.

Kyncl (1986) Pharmacology of tera. Am.J.Med. 80 12 PMID: 2872801

Hancock et al (1995) Actions of tera. and its enantiomers at subtypes of α1- and α2-adrenoceptors in vitro. J.Recept.Signal Transduct.Res. 15 863 PMID: 8673721

Maruyama et al (1994) Comparison of displacemental potencies of tera. enantiomers for α1-adrenoceptor subtypes. Biol.Pharm.Bull. 17 1126 PMID: 7820122

If you know of a relevant reference for Terazosin hydrochloride, please let us know.

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2 Citations for Terazosin hydrochloride

Citations are publications that use Tocris products. Selected citations for Terazosin hydrochloride include:

Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566

Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037

Do you know of a great paper that uses Terazosin hydrochloride from Tocris? Please let us know.

Reviews for Terazosin hydrochloride

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Used to investigate cell metabolism.
By Anonymous on 12/22/2022
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Primary hippocampal neurons

The drug was incubated at 10 μM to investigate an effect on cell metabolism.

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.