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Biological Activity for Silodosin
Silodosin is a selective α1A adrenoceptor antagonist (Ki = 0.036 nM). Displays >55 fold selectivity for α1A over α1B and α1D. Inhibits norepinephrine-induced [Ca2+]I increase in α1A expressing CHO cells (IC50 = 0.32 nM). Inhibits norepinephrine-induced contraction of isolated human prostate tissue.
Compound Libraries for Silodosin
Technical Data for Silodosin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Silodosin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Silodosin
The following data is based on the product molecular weight 495.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.02 mL||10.09 mL||20.18 mL|
|5 mM||0.4 mL||2.02 mL||4.04 mL|
|10 mM||0.2 mL||1.01 mL||2.02 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for Silodosin
References are publications that support the biological activity of the product.
Shibata et al (1995) KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol.Pharmacol. 48 250 PMID: 7651358
Moriyama et al (1997) KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate. Eur.J.Pharmacol. 331 39 PMID: 9274928
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Keywords: Silodosin, Silodosin supplier, alpha, 1a, adrenoceptor, adrenergic, receptor, antagonists, antagonism, KMD-3213, Adrenergic, Alpha-1, Receptors, 6663, Tocris Bioscience
1 Citation for Silodosin
Citations are publications that use Tocris products. Selected citations for Silodosin include:
Wen Cheng et al (2022) A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4. NPJ Genom Med 7 4 PMID: 35046404
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.