Home / Pharmacology / GPCRs / 7-TM Receptors / Adrenergic Receptors / Adrenergic α1 Receptors / Adrenergic α1 Receptor Antagonists / Silodosin

Silodosin

Cat. No. 6663 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Selective α1A antagonist
Chemical Name: 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Silodosin

Silodosin is a selective α1A adrenoceptor antagonist (Ki = 0.036 nM). Displays >55 fold selectivity for α1A over α1B and α1D. Inhibits norepinephrine-induced [Ca2+]I increase in α1A expressing CHO cells (IC50 = 0.32 nM). Inhibits norepinephrine-induced contraction of isolated human prostate tissue.

Compound Libraries for Silodosin

Silodosin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Silodosin

M. Wt 495.53
Formula C25H32F3N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 160970-54-7
PubChem ID 5312125
InChI Key PNCPYILNMDWPEY-QGZVFWFLSA-N
Smiles C[C@@H](NCCOC1=C(C=CC=C1)OCC(F)(F)F)CC2=CC(C(N)=O)=C3N(CCC3=C2)CCCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Silodosin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.55 100
ethanol 49.55 100

Preparing Stock Solutions for Silodosin

The following data is based on the product molecular weight 495.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.09 mL 20.18 mL
5 mM 0.4 mL 2.02 mL 4.04 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for Silodosin

References are publications that support the biological activity of the product.

Shibata et al (1995) KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol.Pharmacol. 48 250 PMID: 7651358

Moriyama et al (1997) KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate. Eur.J.Pharmacol. 331 39 PMID: 9274928

If you know of a relevant reference for Silodosin, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Adrenergic α1 Receptor Antagonists

Keywords: Silodosin, Silodosin supplier, alpha, 1a, adrenoceptor, adrenergic, receptor, antagonists, antagonism, KMD-3213, Adrenergic, Alpha-1, Receptors, 6663, Tocris Bioscience

1 Citation for Silodosin

Citations are publications that use Tocris products. Selected citations for Silodosin include:

Wen Cheng et al (2022) A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4. NPJ Genom Med 7 4 PMID: 35046404

Do you know of a great paper that uses Silodosin from Tocris? Please let us know.

Reviews for Silodosin

There are currently no reviews for this product. Be the first to review Silodosin and earn rewards!

Have you used Silodosin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.