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Description: Selective hα1A adrenergic receptor fluorescent antagonist
Purity: ≥95% (HPLC)
Literature (2)

Biological Activity for CELT-133

CELT-133 is a selective hα1A adrenergic receptor fluorescent antagonist. It shows full selectivity for α1A over α2A (Ki= 5 nM and 15% of displacement at 1 μM respectively in radioligand binding assay). CELT-133 binds equally to all subtypes of α1 adrenergic receptor. Excitation and emission maxima (λ) are 560 and 571 nm, respectively. Wavelengths are compatible with use as an acceptor dye in TR-FRET assays, together with the CoraFluor™ 1 (Cat. No. 7920) TR-FRET donor.

Add 76 μL of assay buffer containing 1% of DMSO to obtain a 100 μM stock solution, and use 250 nM as a working concentration.

Licensing Information

Sold under license from Celtarys Research

Optical Data for CELT-133

Emission Color Yellow
λabs 560 nm
λem 571 nm
Application Fluorescence polarization, Confocal microscopy, High content screening

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Technical Data for CELT-133

M. Wt 1318.43
Storage Store at -20°C
Purity ≥95% (HPLC)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CELT-133

References are publications that support the biological activity of the product.

Kenny et al (1996) Evaluation of the pharmacological selectivity profile of alpha 1 adrenoceptor antagonists at prostatic alpha 1 adrenoceptors: binding, functional and in vivo studies. Br.J.Pharmacol. 118 871 PMID: 8799556

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Keywords: CELT-133, CELT-133 supplier, adrenergic, alpha1A, receptor, ligand, fluorescent, probe, fluorescence, TR-FRET, assay, Fluorescent, Receptor, Probes, and, FP, Assay, Reagents, Adrenergic, Alpha-1, Receptors, 7952, Tocris Bioscience

Citations for CELT-133

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