Carvedilol

Pricing Availability Delivery Time Qty
Cat.No. 2685 - Carvedilol | C24H26N2O4 | CAS No. 72956-09-3
Description: β-adrenoceptor and α1-adrenoceptor antagonist
Alternative Names: BM 14190
Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent β-adrenoceptor and α1-adrenoceptor antagonist (Ki values are 0.81, 0.96 and 2.2 nM for β1-, β2- and α1-adrenoceptors respectively) that displays antihypertensive and peripheral vasodilatory activity. Blocks cardiac inward-rectifier K+ (KIR) channels, voltage-dependent Ca2+ channels and exhibits antioxidant properties at higher concentrations.

Compound Libraries

Carvedilol is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 406.47
Formula C24H26N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 72956-09-3
PubChem ID 2585
InChI Key OGHNVEJMJSYVRP-UHFFFAOYSA-N
Smiles COC1=C(OCCNCC(O)COC2=CC=CC3=C2C2=C(N3)C=CC=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.64 100
ethanol 20.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 406.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.46 mL 12.3 mL 24.6 mL
5 mM 0.49 mL 2.46 mL 4.92 mL
10 mM 0.25 mL 1.23 mL 2.46 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Ponicke et al (2002) Differential effects of bucindolol and carvedilol on noradrenaline-induced hypertonic response in ventricular cardiomyocytes of adult rats. J.Pharmacol.Exp.Ther. 301 71 PMID: 11907159

Kikuta et al (2006) Carvedilol blocks cardiac KATP and KG but not IK1 channels by acting at the bundle-crossing region. Eur.J.Pharmacol. 529 47 PMID: 16325804

Ohlstein et al (1993) Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc.Natl.Acad.Sci.USA. 90 6189 PMID:


If you know of a relevant reference for Carvedilol, please let us know.

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2 Citations for Carvedilol

Citations are publications that use Tocris products. Selected citations for Carvedilol include:

Baker et al (2011) Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. FASEB J 25 4486 PMID: 21865315

Ajmo et al (2009) Blockade of adrenoreceptors inhibits the splenic response to stroke. Nat Commun 218 47 PMID: 19371742


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Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
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  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
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GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
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  • Frizzled Receptors
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Depression Poster

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Pathways for Carvedilol

Protocols

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