Tamsulosin hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3050 - Tamsulosin hydrochloride | C20H28N2O5S.HCl | CAS No. 106463-17-6
Description: Selective α1A antagonist
Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-benzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.

Compound Libraries

Tamsulosin hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 444.97
Formula C20H28N2O5S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 106463-17-6
PubChem ID 5362376
InChI Key ZZIZZTHXZRDOFM-XFULWGLBSA-N
Smiles C[C@@H](NCCOC2=CC=CC=C2OCC)CC1=CC=C(OC)C(S(=O)(N)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 44.5 100
water 4.45 10

Preparing Stock Solutions

The following data is based on the product molecular weight 444.97. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.25 mL 11.24 mL 22.47 mL
5 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.25 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1 PMID: 7781702

Taguchi et al (1997) Effects of tamsulosin metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1 PMID: 8996174

Ohtake et al (2005) Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345 PMID:


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1 Citation for Tamsulosin hydrochloride

Citations are publications that use Tocris products. Selected citations for Tamsulosin hydrochloride include:

Trevisani et al (2005) Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways. Br J Pharmacol 145 1123 PMID: 15937520


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