Tamsulosin hydrochloride

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Cat.No. 3050 - Tamsulosin hydrochloride | C20H28N2O5S.HCl | CAS No. 106463-17-6
Description: Selective α1A antagonist
Chemical Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
Purity: ≥99% (HPLC)
Citations (3)
Literature (4)

Biological Activity

Selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.

Compound Libraries

Tamsulosin hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 444.97
Formula C20H28N2O5S.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 106463-17-6
PubChem ID 5362376
Smiles C[C@@H](NCCOC2=CC=CC=C2OCC)CC1=CC=C(OC)C(S(=O)(N)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 4.45 10
DMSO 44.5 100

Preparing Stock Solutions

The following data is based on the product molecular weight 444.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.25 mL 11.24 mL 22.47 mL
5 mM 0.45 mL 2.25 mL 4.49 mL
10 mM 0.22 mL 1.12 mL 2.25 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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References are publications that support the biological activity of the product.

Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1 PMID: 7781702

Taguchi et al (1997) Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1 PMID: 8996174

Ohtake et al (2005) Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345

If you know of a relevant reference for Tamsulosin hydrochloride, please let us know.

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3 Citations for Tamsulosin hydrochloride

Citations are publications that use Tocris products. Selected citations for Tamsulosin hydrochloride include:

Trevisani et al (2005) Hydrogen sulfide causes vanilloid receptor 1-mediated neurogenic inflammation in the airways. Br J Pharmacol 145 1123 PMID: 15937520

Xiao et al (2019) Acute tobacco smoke exposure exacerbates the inflammatory response to corneal wounds in mice via the sympathetic nervous system. Commun Biol 2 33 PMID: 30701198

Kunit et al (2014) Inhibition of smooth muscle force generation by focal adhesion kinase inhibitors in the hyperplastic human prostate. Am J Physiol Renal Physiol 307 F823 PMID: 25056351

Do you know of a great paper that uses Tamsulosin hydrochloride from Tocris? Please let us know.

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Literature in this Area

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