A 61603 hydrobromide

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Description: α1A agonist
Chemical Name: N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide
Citations (12)
Literature (1)

Biological Activity for A 61603 hydrobromide

A 61603 hydrobromide is a potent α-adrenoceptor agonist that is at least 35-fold more potent at α1A than at α1B or α1D sites. Induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L).

Technical Data for A 61603 hydrobromide

M. Wt 390.29
Formula C14H19N3O3S.HBr
Storage Desiccate at +4°C
CAS Number 107756-30-9
PubChem ID 9865178
Smiles Br.CS(=O)(=O)NC1=C(O)C=CC2=C1CCCC2C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for A 61603 hydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 50

Preparing Stock Solutions for A 61603 hydrobromide

The following data is based on the product molecular weight 390.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.12 mL 25.62 mL 51.24 mL
2.5 mM 1.02 mL 5.12 mL 10.25 mL
5 mM 0.51 mL 2.56 mL 5.12 mL
25 mM 0.1 mL 0.51 mL 1.02 mL

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Product Datasheets for A 61603 hydrobromide

Certificate of Analysis / Product Datasheet
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References for A 61603 hydrobromide

References are publications that support the biological activity of the product.

Knepper et al (1995) A-61603, a potent α1-adrenergic receptor agonist, selective for the α1A receptor subtype. J.Pharmacol.Exp.Ther. 274 97 PMID: 7616455

Luo et al (2007) Receptor subtype involved in α1A-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 28 968 PMID: 17588332

Meyer et al (1996) Synthesis and in vitro characterisation of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective α1A receptor agonist. J.Med.Chem. 39 4116 PMID: 8831777

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Keywords: A 61603 hydrobromide, A 61603 hydrobromide supplier, α1A-adrenoceptor, alpha1A-adrenoceptor, agonists, α1a-adrenergic, alpha1a-adrenergic, a1a-adrenergic, a1a-adrenoceptor, Receptors, A61603, hydrobromide, α1a, Adrenergic, Alpha-1, 1052, Tocris Bioscience

12 Citations for A 61603 hydrobromide

Citations are publications that use Tocris products. Selected citations for A 61603 hydrobromide include:

Copik et al (2015) Isoproterenol acts as a biased agonist of the α-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. PLoS One 10 e0115701 PMID: 25606852

Amirak et al (2013) p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists. Biochem J 450 351 PMID: 23215897

Dash et al (2011) A molecular MRI probe to detect treatment of cardiac apoptosis in vivo. Magn Reson Med 66 1152 PMID: 21360750

Thomas et al (2016) A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci 1 155 PMID: 27453955

Do you know of a great paper that uses A 61603 hydrobromide from Tocris? Please let us know.

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Literature in this Area

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