Cirazoline hydrochloride

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Cat.No. 0888 - Cirazoline hydrochloride | C13H16N2O.HCl | CAS No. 40600-13-3
Description: Selective α1 agonist
Chemical Name: 2-(2-Cyclopropylphenoxymethyl)imidazoline hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Selective α1 agonist. Also available as part of the α1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™.

Compound Libraries

Cirazoline hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 252.74
Formula C13H16N2O.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 40600-13-3
PubChem ID 11957512
InChI Key XFRXWLWUUDJHPB-UHFFFAOYSA-N
Smiles Cl.C(OC1=C(C=CC=C1)C1CC1)C1=NCCN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.27 100
water 25.27 100

Preparing Stock Solutions

The following data is based on the product molecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.96 mL 19.78 mL 39.57 mL
5 mM 0.79 mL 3.96 mL 7.91 mL
10 mM 0.4 mL 1.98 mL 3.96 mL
50 mM 0.08 mL 0.4 mL 0.79 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Le Rouzic et al (1995) Binding of [3H]cirazoline to an imidazoline site in rat brain and kidney membranes. Eur.J.Pharmacol. 278 261 PMID: 7589165

Gellai and Ruffolo (1987) Renal effects of selective alpha-1 and alpha-2 adrenoreceptor agonists in conscious normotensive rats. J.Pharmacol.Exp.Ther. 240 723 PMID: 2882013

Wikberg and Uklen (1990) Further characterisation of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug. J.Neurochem. 55 192 PMID: 1972387


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View all Adrenergic α1 Receptor Agonists

Keywords: Cirazoline hydrochloride, supplier, Selective, α1, α1-adrenoceptor, alpha1-adrenoceptor, α1-adrenergic, alpha1-adrenergic, a1-adrenoceptor, a1-adrenergic, agonists, Imidazoline, ligands, Receptors, General, Imidazolines, Adrenergic, Alpha-1, Receptors, General, Imidazolines, Adrenergic, Alpha-1, Receptors, Tocris Bioscience

2 Citations for Cirazoline hydrochloride

Citations are publications that use Tocris products. Selected citations for Cirazoline hydrochloride include:

Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650

Montgomery (2017) An Alpha-1A Adrenergic Receptor Agonist Prevents Acute Doxorubicin Cardiomyopathy in Male Mice. Plos One 12 e0168409 PMID: 28081170


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