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Selective α1 agonist.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 252.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.96 mL||19.78 mL||39.57 mL|
|5 mM||0.79 mL||3.96 mL||7.91 mL|
|10 mM||0.4 mL||1.98 mL||3.96 mL|
|50 mM||0.08 mL||0.4 mL||0.79 mL|
References are publications that support the biological activity of the product.
Le Rouzic et al (1995) Binding of [3H]cirazoline to an imidazoline site in rat brain and kidney membranes. Eur.J.Pharmacol. 278 261 PMID: 7589165
Gellai and Ruffolo (1987) Renal effects of selective alpha-1 and alpha-2 adrenoreceptor agonists in conscious normotensive rats. J.Pharmacol.Exp.Ther. 240 723 PMID: 2882013
Wikberg and Uklen (1990) Further characterisation of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor-selective drug. J.Neurochem. 55 192 PMID: 1972387
If you know of a relevant reference for Cirazoline hydrochloride, please let us know.
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Keywords: Cirazoline hydrochloride, Cirazoline hydrochloride supplier, Selective, α1, α1-adrenoceptor, alpha1-adrenoceptor, α1-adrenergic, alpha1-adrenergic, a1-adrenoceptor, a1-adrenergic, agonists, Imidazoline, ligands, Receptors, General, Imidazolines, Adrenergic, Alpha-1, 0888, Tocris Bioscience
4 Citations for Cirazoline hydrochloride
Citations are publications that use Tocris products. Selected citations for Cirazoline hydrochloride include:
Kahn et al (2016) The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway. EMBO Mol Med 8 511 PMID: 27138566
Montgomery (2017) An Alpha-1A Adrenergic Receptor Agonist Prevents Acute dox. Cardiomyopathy in Male Mice. Plos One 12 e0168409 PMID: 28081170
Bhattachariya et al (2014) PYK2 selectively mediates signals for growth versus differentiation in response to stretch of spontaneously active vascular smooth muscle. Physiol Rep 2 PMID: 25347863
Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650
Do you know of a great paper that uses Cirazoline hydrochloride from Tocris? Please let us know.
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.