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α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 203.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.91 mL||24.55 mL||49.1 mL|
|5 mM||0.98 mL||4.91 mL||9.82 mL|
|10 mM||0.49 mL||2.45 mL||4.91 mL|
|50 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929 PMID: 7969082
Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127 PMID: 9249248
Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072
If you know of a relevant reference for (R)-(-)-Phenylephrine hydrochloride, please let us know.
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Keywords: (R)-(-)-Phenylephrine hydrochloride, (R)-(-)-Phenylephrine hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, agonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, Adrenergic, Alpha-1, 2838, Tocris Bioscience
4 Citations for (R)-(-)-Phenylephrine hydrochloride
Citations are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:
Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. PLoS One 13 584 PMID: 21531340
Jin et al (2015) Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. J Neurosci 10 e0126956 PMID: 25962147
Li et al (2016) Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway. PLoS One 11 e0159079 PMID: 27438013
Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653
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Elicits calcium increase in astrocytes at 100uM
Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.