α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 203.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.91 mL||24.55 mL||49.1 mL|
|5 mM||0.98 mL||4.91 mL||9.82 mL|
|10 mM||0.49 mL||2.45 mL||4.91 mL|
|50 mM||0.1 mL||0.49 mL||0.98 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929 PMID: 7969082
Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127 PMID: 9249248
Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072
If you know of a relevant reference for (R)-(-)-Phenylephrine hydrochloride, please let us know.
View Related Products by Product Action
Keywords: α1-adrenoceptor alpha1-adrenoceptor a1-adrenoceptor agonists a1-adrenergic α1-adrenergic alpha1-adrenergic Receptors Adrenergic Alpha-1 Receptors
2 Citations for (R)-(-)-Phenylephrine hydrochloride
Citations are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:
Jin et al (2015) Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. J Neurosci 10 e0126956 PMID: 25962147
Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. PLoS One 13 584 PMID: 21531340
Do you know of a great paper that uses (R)-(-)-Phenylephrine hydrochloride from Tocris? If so please let us know.
Literature in this Area
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.