(R)-(-)-Phenylephrine hydrochloride

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Description: α1 agonist
Chemical Name: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Purity: ≥99% (HPLC)
Citations (4)
Reviews (1)
Literature (1)

Biological Activity for (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride is a α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Compound Libraries for (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for (R)-(-)-Phenylephrine hydrochloride

M. Wt 203.67
Formula C9H13NO2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 61-76-7
PubChem ID 441279
Smiles OC1=CC=CC([C@@H](O)CNC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-(-)-Phenylephrine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 20.37 100
DMSO 20.37 100

Preparing Stock Solutions for (R)-(-)-Phenylephrine hydrochloride

The following data is based on the product molecular weight 203.67. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.91 mL 24.55 mL 49.1 mL
5 mM 0.98 mL 4.91 mL 9.82 mL
10 mM 0.49 mL 2.45 mL 4.91 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets for (R)-(-)-Phenylephrine hydrochloride

References for (R)-(-)-Phenylephrine hydrochloride

References are publications that support the biological activity of the product.

Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929 PMID: 7969082

Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127 PMID: 9249248

Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072

If you know of a relevant reference for (R)-(-)-Phenylephrine hydrochloride, please let us know.

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Keywords: (R)-(-)-Phenylephrine hydrochloride, (R)-(-)-Phenylephrine hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, agonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, Adrenergic, Alpha-1, 2838, Tocris Bioscience

4 Citations for (R)-(-)-Phenylephrine hydrochloride

Citations are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:

Jin et al (2015) Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. J Neurosci 10 e0126956 PMID: 25962147

Chai et al (2017) Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron 95 531 PMID: 28712653

Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. PLoS One 13 584 PMID: 21531340

Li et al (2016) Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway. PLoS One 11 e0159079 PMID: 27438013

Do you know of a great paper that uses (R)-(-)-Phenylephrine hydrochloride from Tocris? Please let us know.

Reviews for (R)-(-)-Phenylephrine hydrochloride

Average Rating: 5 (Based on 1 Review.)

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Adrenergic agonist.
By Anonymous on 10/02/2018
Assay Type: In Vivo
Species: Mouse

Elicits calcium increase in astrocytes at 100uM

Literature in this Area

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.