(R)-(-)-Phenylephrine hydrochloride

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Cat.No. 2838 - (R)-(-)-Phenylephrine hydrochloride | C9H13NO2.HCl | CAS No. 61-76-7
Description: α1 agonist
Chemical Name: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Technical Data

M. Wt 203.67
Formula C9H13NO2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 61-76-7
PubChem ID 441279
InChI Key OCYSGIYOVXAGKQ-FVGYRXGTSA-N
Smiles OC1=CC=CC([C@@H](O)CNC)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.37 100
water 20.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 203.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.91 mL 24.55 mL 49.1 mL
5 mM 0.98 mL 4.91 mL 9.82 mL
10 mM 0.49 mL 2.45 mL 4.91 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929 PMID: 7969082

Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127 PMID: 9249248

Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072


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2 Citations for (R)-(-)-Phenylephrine hydrochloride

Citations are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:

Jin et al (2015) Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. J Neurosci 10 e0126956 PMID: 25962147

Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. PLoS One 13 584 PMID: 21531340


Do you know of a great paper that uses (R)-(-)-Phenylephrine hydrochloride from Tocris? If so please let us know.

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