α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 203.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.91 mL||24.55 mL||49.1 mL|
|5 mM||0.98 mL||4.91 mL||9.82 mL|
|10 mM||0.49 mL||2.45 mL||4.91 mL|
|50 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929 PMID: 7969082
Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127 PMID: 9249248
Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072
If you know of a relevant reference for (R)-(-)-Phenylephrine hydrochloride, please let us know.
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2 Citations for (R)-(-)-Phenylephrine hydrochloride
Citations are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:
Jin et al (2015) Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus. J Neurosci 10 e0126956 PMID: 25962147
Lam et al (2011) Leptin does not directly affect CNS serotonin neurons to influence appetite. PLoS One 13 584 PMID: 21531340
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.