HEAT hydrochloride

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Cat.No. 0535 - HEAT hydrochloride | C19H21NO2.HCl | CAS No. 30007-39-7
Description: Highly selective α1 antagonist
Alternative Names: BE 2254
Chemical Name: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Very selective α1-adrenoceptor antagonist, precursor of the 3-[125I]-derivative.

Technical Data

M. Wt 331.84
Formula C19H21NO2.HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 30007-39-7
PubChem ID 34771
InChI Key VCZXZECZIRGUCZ-UHFFFAOYSA-N
Smiles Cl.OC1=CC=C(CCNCC2CCC3=CC=CC=C3C2=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 331.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Baumgarten et al (1972) Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats. Naunyn Schmiedebergs Arch.Pharmacol. 274 375 PMID: 4404780

Williams et al (1978) Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes. J.Pharm.Pharmacol. 30 390 PMID: 26778


If you know of a relevant reference for HEAT hydrochloride, please let us know.

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View all Adrenergic α1 Receptor Antagonists

Keywords: selective α1-adrenoceptor alpha1-adrenoceptor a1-adrenoceptor antagonists a1-adrenergic α1-adrenergic alpha1-adrenergic Receptors BE2254 2-{[b-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride BE 2254 Adrenergic Alpha-1 Receptors

3 Citations for HEAT hydrochloride

Citations are publications that use Tocris products. Selected citations for HEAT hydrochloride include:

Grisanti et al (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther 338 648 PMID: 21571945

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Circ Res 24 7745 PMID: 15342742

Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341


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Pathways for HEAT hydrochloride

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