HEAT hydrochloride

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Cat.No. 0535 - HEAT hydrochloride | C19H21NO2.HCl | CAS No. 30007-39-7
Description: Highly selective α1 antagonist
Alternative Names: BE 2254
Chemical Name: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (4)

Biological Activity

Very selective α1-adrenoceptor antagonist, precursor of the 3-[125I]-derivative.

Technical Data

M. Wt 331.84
Formula C19H21NO2.HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 30007-39-7
PubChem ID 34771
InChI Key VCZXZECZIRGUCZ-UHFFFAOYSA-N
Smiles Cl.OC1=CC=C(CCNCC2CCC3=CC=CC=C3C2=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 331.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.14 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References

References are publications that support the biological activity of the product.

Baumgarten et al (1972) Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats. Naunyn Schmiedebergs Arch.Pharmacol. 274 375 PMID: 4404780

Williams et al (1978) Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes. J.Pharm.Pharmacol. 30 390 PMID: 26778


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View all Adrenergic α1 Receptor Antagonists

Keywords: HEAT hydrochloride, HEAT hydrochloride supplier, selective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, BE2254, 2-{[b-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone, hydrochloride, BE, 2254, Adrenergic, Alpha-1, 0535, Tocris Bioscience

3 Citations for HEAT hydrochloride

Citations are publications that use Tocris products. Selected citations for HEAT hydrochloride include:

Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Circ Res 24 7745 PMID: 15342742

Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341

Grisanti et al (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther 338 648 PMID: 21571945


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Literature in this Area

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