Ubiquitin E3 Ligase Inhibitors

Cat No Product Name / Activity
5397 A01
High affinity Smurf1 inhibitor; enhances BMP signaling
5747 Apcin
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
6157 cis VH 298
Negative control for VH 298
5636 GS 143
β-TrCP1 ligase inhibitor
5433 Heclin
HECT E3 ubiquitin ligase inhibitor
3503 HLI 373
Hdm2 inhibitor; activates p53-dependent transcription
2936 NSC 66811
MDM2 antagonist. Disrupts MDM2-p53 interaction
3984 Nutlin-3
MDM2 antagonist; inhibits MDM2-p53 interaction
6075 Nutlin 3a
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
6302 Pomalidomide
Cereblon ubiquitination inhibitor; also TNF-α inhibitor and antiangiogenic
5047 PRT 4165
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
5191 PTC 209
Bmi-1 inhibitor; antitumor
2443 RITA
MDM2-p53 interaction inhibitor
4817 SKPin C1
Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
4375 SMER 3
Selective inhibitor of E3 ubiquitin ligase
5332 SP 141
High affinity MDM2 inhibitor
5076 SZL P1-41
Selective Skp2 inhibitor; suppresses E3 ligase activity
4506 TAME hydrochloride
Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination
0652 Thalidomide
Binds cereblon, inhibiting ubiquitin ligase activity; alsoTNF-a synthesis inhibitor
6156 VH 298
High-affinity inhibitor of VHL