Ubiquitin E3 Ligase Inhibitors

Cat. No. Product Name / Activity
5397 A01
High affinity Smurf1 inhibitor; enhances BMP signaling
5747 Apcin
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
7715 C25-140
TRAF6-Ubc13 interaction inhibitor
7089 CSN5i-3
Potent and selective CSN5 (COP9 signalosome) inhibitor
7852 EM12-SO2F
Potent covalent inhibitor of Cereblon
5636 GS 143
β-TrCP1 ligase inhibitor
5433 Heclin
HECT E3 ubiquitin ligase inhibitor
3503 HLI 373
Hdm2 inhibitor; activates p53-dependent transcription
6904 Idasanutlin
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
7289 Nimbolide
RNF114 inhibitor
3984 Nutlin-3
MDM2 antagonist; inhibits MDM2-p53 interaction
6075 Nutlin 3a
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
5047 PRT 4165
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
5191 PTC 209
Bmi-1 inhibitor; antitumor
2443 RITA
MDM2-p53 interaction inhibitor
7542 SJ 1008066
MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
4375 SMER 3
Selective inhibitor of E3 ubiquitin ligase
7192 SMIP 004
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
5332 SP 141
High affinity MDM2 inhibitor
7498 SPOP-i-6lc
SPOP E3 ubiquitin ligase inhibitor
5076 SZL P1-41
Selective Skp2 inhibitor; suppresses E3 ligase activity
0652 Thalidomide
Binds cereblon; also TNF-α synthesis inhibitor
7774 VH 032
Inhibitor of VHL; blocks interaction of VHL and HIF-α
6156 VH 298
High-affinity inhibitor of VHL
7903 VL 285
VHL inhibitor
7055 WS 383
Potent, selective and reversible DCN1-UBC12 interaction inhibitor