Ubiquitin E3 Ligase Inhibitors
| Cat. No. | Product Name / Activity |
|---|---|
| 5747 | Apcin |
| Cdc20 inhibitor; inhibits Cdc20-substrate interaction | |
| 7715 | C25-140 |
| TRAF6-Ubc13 interaction inhibitor | |
| 8044 | CHIPOpt |
| CHIP/STUB1 E3 ligase inhibitor | |
| 7089 | CSN5i-3 |
| Potent and selective CSN5 (COP9 signalosome) inhibitor | |
| 7852 | EM12-SO2F |
| Potent covalent inhibitor of Cereblon | |
| 5636 | GS 143 |
| β-TrCP1 ligase inhibitor | |
| 5433 | Heclin |
| HECT E3 ubiquitin ligase inhibitor | |
| 3503 | HLI 373 |
| Hdm2 inhibitor; activates p53-dependent transcription | |
| 6904 | Idasanutlin |
| Potent MDM2 inhibitor; inhibits MDM2-p53 interaction | |
| 8091 | KH-4-43 |
| Selective CUL4 inhibitor | |
| 7289 | Nimbolide |
| RNF114 inhibitor | |
| 3984 | Nutlin-3 |
| MDM2 antagonist; inhibits MDM2-p53 interaction | |
| 6075 | Nutlin 3a |
| MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984) | |
| 8950 | NX 1607 |
| CBL-B intramolecular glue inhibitor | |
| 5047 | PRT 4165 |
| Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination | |
| 2443 | RITA |
| MDM2-p53 interaction inhibitor | |
| 7542 | SJ 1008066 |
| MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction | |
| 4375 | SMER 3 |
| Selective inhibitor of E3 ubiquitin ligase | |
| 7192 | SMIP 004 |
| SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase | |
| 5332 | SP 141 |
| High affinity MDM2 inhibitor | |
| 7498 | SPOP-i-6lc |
| SPOP E3 ubiquitin ligase inhibitor | |
| 5076 | SZL P1-41 |
| Selective Skp2 inhibitor; suppresses E3 ligase activity | |
| 0652 | Thalidomide |
| Binds cereblon; also TNF-α synthesis inhibitor | |
| 7774 | VH 032 |
| Inhibitor of VHL; blocks interaction of VHL and HIF-α | |
| 6156 | VH 298 |
| High-affinity inhibitor of VHL | |
| 7903 | VL 285 |
| VHL inhibitor | |
| 7055 | WS 383 |
| Potent, selective and reversible DCN1-UBC12 interaction inhibitor |
Targeted Protein Degradation and Induced Proximity Guide
This brochure highlights the products and services available from Bio-Techne to support Targeted Protein Degradation and Induced Proximity research.
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