Ubiquitin E3 Ligase Inhibitors

Cat. No.	Product Name / Activity
5397	A01
	High affinity Smurf1 inhibitor; enhances BMP signaling
5747	Apcin
	Cdc20 inhibitor; inhibits Cdc20-substrate interaction
7715	C25-140 New
	TRAF6-Ubc13 interaction inhibitor
7089	CSN5i-3
	Potent and selective CSN5 (COP9 signalosome) inhibitor
5636	GS 143
	β-TrCP1 ligase inhibitor
5433	Heclin
	HECT E3 ubiquitin ligase inhibitor
3503	HLI 373
	Hdm2 inhibitor; activates p53-dependent transcription
6904	Idasanutlin
	Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
7289	Nimbolide
	RNF114 inhibitor
3984	Nutlin-3
	MDM2 antagonist; inhibits MDM2-p53 interaction
6075	Nutlin 3a
	MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
5047	PRT 4165
	Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
5191	PTC 209
	Bmi-1 inhibitor; antitumor
2443	RITA
	MDM2-p53 interaction inhibitor
7542	SJ 1008066
	MAGE-A11 inhibitor disrupts MAGE-A11:PCF11 interaction
4375	SMER 3
	Selective inhibitor of E3 ubiquitin ligase
7192	SMIP 004
	SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G₁ phase
5332	SP 141
	High affinity MDM2 inhibitor
7498	SPOP-i-6lc
	SPOP E3 ubiquitin ligase inhibitor
5076	SZL P1-41
	Selective Skp2 inhibitor; suppresses E3 ligase activity
0652	Thalidomide
	Binds cereblon; also TNF-α synthesis inhibitor
6156	VH 298
	High-affinity inhibitor of VHL
7055	WS 383
	Potent, selective and reversible DCN1-UBC12 interaction inhibitor
6719	YH 239-EE
	MDM2 inhibitor; disrupts MDM2-p53 interaction