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Biological Activity for Nutlin-3
Nutlin-3 is a MDM2 antagonist; inhibits the MDM2-p53 interaction (IC50 = 0.09 μM) and activates p53. Antiproliferative agent; induces apoptosis in cancer cells.
Sold under license from F. Hoffmann-La Roche Ltd.
Compound Libraries for Nutlin-3
Technical Data for Nutlin-3
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Nutlin-3
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Nutlin-3
The following data is based on the product molecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.72 mL||8.6 mL||17.2 mL|
|5 mM||0.34 mL||1.72 mL||3.44 mL|
|10 mM||0.17 mL||0.86 mL||1.72 mL|
|50 mM||0.03 mL||0.17 mL||0.34 mL|
References for Nutlin-3
References are publications that support the biological activity of the product.
Vassilev et al (2004) In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 844 PMID: 14704432
If you know of a relevant reference for Nutlin-3, please let us know.
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Keywords: Nutlin-3, Nutlin-3 supplier, Nutlin3, p53, activator, MDM2, antagonist, antagonists, p53-MDM2, Ubiquitin, E3, Ligases, 3984, Tocris Bioscience
3 Citations for Nutlin-3
Citations are publications that use Tocris products. Selected citations for Nutlin-3 include:
Yang et al (2016) A redox mechanism underlying nucleolar stress sensing by nucleophosmin. Nat Commun 7 13599 PMID: 27886181
Bussey et al (2016) Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma. J Zhejiang Univ Sci B 5 1 PMID: 26754547
Norlin et al (2018) The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival. Development 145 PMID: 29180572
Do you know of a great paper that uses Nutlin-3 from Tocris? Please let us know.
Reviews for Nutlin-3
Average Rating: 5 (Based on 1 Review.)
Have you used Nutlin-3?
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It worked perfectly at 10microM concentration for 48 hours.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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