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Biological Activity for HLI 373
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.
Compound Libraries for HLI 373
Technical Data for HLI 373
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HLI 373
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for HLI 373
The following data is based on the product molecular weight 414.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.07 mL||24.14 mL|
|5 mM||0.48 mL||2.41 mL||4.83 mL|
|10 mM||0.24 mL||1.21 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References for HLI 373
References are publications that support the biological activity of the product.
Kitagaki et al (2008) Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 7 2445 PMID: 18723490
Yang et al (2009) Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 100 24 PMID: 19037995
If you know of a relevant reference for HLI 373, please let us know.
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Keywords: HLI 373, HLI 373 supplier, Hdm2, inhibitors, inhibits, inhibitor, p53, transcription, activators, HLI373, Ubiquitin, E3, Ligases, 3503, Tocris Bioscience
Citations for HLI 373
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Literature in this Area
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