SMER 3

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Cat.No. 4375 - SMER 3 | C11H4N4O2 | CAS No. 67200-34-4
Description: Selective inhibitor of E3 ubiquitin ligase
Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Technical Data

M. Wt 224.18
Formula C11H4N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 67200-34-4
PubChem ID 568763
InChI Key SFSSAKVWCKFRHE-UHFFFAOYSA-N
Smiles O=C4C2=NC1=NON=C1N=C2C3=CC=CC=C34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.81 75

Preparing Stock Solutions

The following data is based on the product molecular weight 224.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 5.95 mL 29.74 mL 59.48 mL
3.75 mM 1.19 mL 5.95 mL 11.9 mL
7.5 mM 0.59 mL 2.97 mL 5.95 mL
37.5 mM 0.12 mL 0.59 mL 1.19 mL

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References

References are publications that support the biological activity of the product.

Aghajanyy et al (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 28 738 PMID: 20581845


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Citations for SMER 3

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Literature in this Area

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