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Biological Activity for SMER 3
SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).
Compound Libraries for SMER 3
Technical Data for SMER 3
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SMER 3
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SMER 3
The following data is based on the product molecular weight 224.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||5.95 mL||29.74 mL||59.48 mL|
|3.75 mM||1.19 mL||5.95 mL||11.9 mL|
|7.5 mM||0.59 mL||2.97 mL||5.95 mL|
|37.5 mM||0.12 mL||0.59 mL||1.19 mL|
References for SMER 3
References are publications that support the biological activity of the product.
Aghajanyy et al (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 28 738 PMID: 20581845
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Keywords: SMER 3, SMER 3 supplier, SMER3, ubiquitin, E3, ligase, inhibitors, inhibits, Ub, ligases, small-molecule, enhancers, rapamycin, SCF, family, Ubiquitin, Ligases, 4375, Tocris Bioscience
1 Citation for SMER 3
Citations are publications that use Tocris products. Selected citations for SMER 3 include:
Babu L et al (2017) Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads. BMC Pharmacol Toxicol 18 40 PMID: 28577368
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Literature in this Area
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