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Cat.No. 4375 - SMER 3 | C11H4N4O2 | CAS No. 67200-34-4
Description: Selective inhibitor of E3 ubiquitin ligase
Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
Purity: ≥98% (HPLC)

Biological Activity

Selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Technical Data

M. Wt 224.18
Formula C11H4N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 67200-34-4
PubChem ID 568763
Smiles O=C4C2=NC1=NON=C1N=C2C3=CC=CC=C34

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 16.81 75

Preparing Stock Solutions

The following data is based on the product molecular weight 224.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.46 mL 22.3 mL 44.61 mL
5 mM 0.89 mL 4.46 mL 8.92 mL
10 mM 0.45 mL 2.23 mL 4.46 mL
50 mM 0.09 mL 0.45 mL 0.89 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Aghajanyy et al (2010) Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor. Nat.Biotechnol. 28 738 PMID: 20581845

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Keywords: SMER 3, supplier, SMER3, ubiquitin, E3, ligase, inhibitors, inhibits, Ub, ligases, small-molecule, enhancers, rapamycin, SCF, family, Ubiquitin, E3, Ligases, Tocris Bioscience

Citations for SMER 3

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Literature in this Area

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for SMER 3


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