VL 285

Pricing Availability   Qty
Description: VHL inhibitor
Chemical Name: (2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (3)

Biological Activity for VL 285

VL 285 is an E3 ubiquitin ligase VHL inhibitor (IC50= 340 nM). VL 285 treatment competitively reduces or reverses target protein degradation by AU-15330 and HaloPROTAC3 Degraders.

Technical Data for VL 285

M. Wt 532.66
Formula C29H32N4O4S
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1448188-57-5
PubChem ID 71667162
InChI Key HEDFFPYRFJKXQP-VJTSUQJLSA-N
Smiles CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VL 285

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.63 50
ethanol 10.65 20

Preparing Stock Solutions for VL 285

The following data is based on the product molecular weight 532.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.75 mL 18.77 mL 37.55 mL
2.5 mM 0.75 mL 3.75 mL 7.51 mL
5 mM 0.38 mL 1.88 mL 3.75 mL
25 mM 0.08 mL 0.38 mL 0.75 mL

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References for VL 285

References are publications that support the biological activity of the product.

Buckley et al (2015) HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins. ACS Chem.Biol. 10 1831 PMID: 26070106

Xiao et al (2022) Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer. Nature 601 434 PMID: 34937944


If you know of a relevant reference for VL 285, please let us know.

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Citations for VL 285

Citations are publications that use Tocris products.

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Literature in this Area

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