Pricing Availability   Qty
Description: SPOP E3 ubiquitin ligase inhibitor
Chemical Name: 1,5-Dihydro-2-imino-10-methyl-N-[2-(4-methyl-1-piperazinyl)ethyl]-5-oxo-1-[2-(2-thienyl)ethyl]-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for SPOP-i-6lc

SPOP-i-6lc is a selective SPOP E3 ubiquitin ligase inhibitor (IC50 = 2.1 μM and 3.5 μM, in A498 and OS-RC-2 cell lines, respectively). In vitro, SPOP-i-6lc suppresses viability and proliferation of A498 and OS-RC-2 kidney cancer cell lines. SPOP-i-6lc leads to the accumulation of tumor suppressors PTEN and DUSP7 and decreased levels of phosphorylated AKT and ERK in clear-cell renal cell carcinoma (ccRCC) cell lines.

Technical Data for SPOP-i-6lc

M. Wt 505.64
Formula C26H31N7O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2136270-56-7
PubChem ID 155532456

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SPOP-i-6lc

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 2.53 5
DMSO 5.06 10

Preparing Stock Solutions for SPOP-i-6lc

The following data is based on the product molecular weight 505.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.78 mL 98.88 mL 197.77 mL
0.5 mM 3.96 mL 19.78 mL 39.55 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for SPOP-i-6lc

References are publications that support the biological activity of the product.

Dong et al (2020) Structure-activity relationship of SPOP inhibitors against kidney cancer. J.Med.Chem. 63 4849 PMID: 32297747

If you know of a relevant reference for SPOP-i-6lc, please let us know.

View Related Products by Product Action

View all Ubiquitin E3 Ligase Inhibitors

Keywords: SPOP-i-6lc, SPOP-i-6lc supplier, spopi6lc, SPOP, E3, ubiquitin, ligase, inhibitors, inhibits, kidney, cancer, ligases, ubiquitination, prostate, Ubiquitin, Ligases, 7498, Tocris Bioscience

Citations for SPOP-i-6lc

Citations are publications that use Tocris products.

Currently there are no citations for SPOP-i-6lc. Do you know of a great paper that uses SPOP-i-6lc from Tocris? Please let us know.

Reviews for SPOP-i-6lc

There are currently no reviews for this product. Be the first to review SPOP-i-6lc and earn rewards!

Have you used SPOP-i-6lc?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Targeted Protein Degradation Research Product Guide

Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Ubiquitin-Proteasome System Proteins
  • Assays for Protein Degradation
Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia