SZL P1-41

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Cat.No. 5076 - SZL P1-41 | C24H24N2O3S | CAS No. 222716-34-9
Description: Selective Skp2 inhibitor; suppresses E3 ligase activity
Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)

Biological Activity

Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Technical Data

M. Wt 420.52
Formula C24H24N2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 222716-34-9
PubChem ID 1286902
Smiles OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 8.41 20
DMSO 2.1 5 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 420.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.89 mL 59.45 mL 118.9 mL
1 mM 2.38 mL 11.89 mL 23.78 mL
2 mM 1.19 mL 5.95 mL 11.89 mL
10 mM 0.24 mL 1.19 mL 2.38 mL

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References are publications that support the biological activity of the product.

Chan et al (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154 556 PMID: 23911321

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