Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||2.1||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 420.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.89 mL||59.45 mL||118.9 mL|
|1 mM||2.38 mL||11.89 mL||23.78 mL|
|2 mM||1.19 mL||5.95 mL||11.89 mL|
|10 mM||0.24 mL||1.19 mL||2.38 mL|
References are publications that support the biological activity of the product.
Chan et al (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154 556 PMID: 23911321
If you know of a relevant reference for SZL P1-41, please let us know.
View Related Products by Product Action
Keywords: SZL P1-41, SZL P1-41 supplier, SZLP1-41, Selective, Skp2, inhibitors, inhibits, suppresses, E3, ligase, SCF, complexes, antitumor, p27, Akt, ubiquitination, cell, senescence, glycolysis, Ubiquitin, Ligases, 5076, Tocris Bioscience
Citations for SZL P1-41
Citations are publications that use Tocris products.
Currently there are no citations for SZL P1-41. Do you know of a great paper that uses SZL P1-41 from Tocris? Please let us know.
Reviews for SZL P1-41
There are currently no reviews for this product. Be the first to review SZL P1-41 and earn rewards!
Have you used SZL P1-41?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.