SZL P1-41

Pricing Availability Delivery Time Qty
Cat.No. 5076 - SZL P1-41 | C24H24N2O3S | CAS No. 222716-34-9
Description: Selective Skp2 inhibitor; suppresses E3 ligase activity
Chemical Name: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Skp2 inhibitor; thought to prevent assembly of Skp2-Skp1 complexes. Selectively suppresses Skp2 SCF E3 ligase activity but exhibits no effect on the activity of other SCF complexes. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Exhibits antitumor effects in multiple animal models and cancer cell lines.

Technical Data

M. Wt 420.52
Formula C24H24N2O3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 222716-34-9
PubChem ID 1286902
InChI Key JKIXLEKBXHMXTN-UHFFFAOYSA-N
Smiles OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 8.41 20
DMSO 2.1 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 420.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chan et al (2013) Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell 154 556 PMID: 3911321


If you know of a relevant reference for SZL P1-41, please let us know.

View Related Products by Product Action

View all Ubiquitin E3 Ligase Inhibitors

Keywords: SZLP1-41 Selective Skp2 inhibitors inhibits suppresses E3 ligase SCF complexes antitumor p27 Akt ubiquitination cell senescence glycolysis Ubiquitin E3 Ligases

Citations for SZL P1-41

Citations are publications that use Tocris products.

Currently there are no citations for SZL P1-41. Do you know of a great paper that uses SZL P1-41 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for SZL P1-41

Protocols

TODO: Add Protocols