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Biological Activity for GS 143
GS 143 is a β-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.
Compound Libraries for GS 143
Technical Data for GS 143
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GS 143
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GS 143
The following data is based on the product molecular weight 466.46. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.14 mL||10.72 mL||21.44 mL|
|5 mM||0.43 mL||2.14 mL||4.29 mL|
|10 mM||0.21 mL||1.07 mL||2.14 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References for GS 143
References are publications that support the biological activity of the product.
Nakajima et al (2008) A novel small-molecule inhibitor of NF-κB signaling. Biochem.Biophys.Res.Comm. 368 1007 PMID: 18275844
Hirose et al (2008) GS143, an IκB ubiquitination inhibitor, inhibits allergic airway inflammation in mice. Biochem.Biophys.Res.Comm. 374 507 PMID: 18656449
If you know of a relevant reference for GS 143, please let us know.
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Keywords: GS 143, GS 143 supplier, GS143, E3, ubiquitin, ligase, ubiquitination, inhibits, inhibitors, NFkappaB, NFκB, NFKB, anti-inflammatory, inflammation, Beta-TrCP1, B-TrCP1, βTrCP1, Ubiquitin, Ligases, 5636, Tocris Bioscience
2 Citations for GS 143
Citations are publications that use Tocris products. Selected citations for GS 143 include:
Smadar et al (2018) Periostin in cardiovascular disease and development: a tale of two distinct roles. Basic Res Cardiol 113 1 PMID: 29101484
Robert R et al (2021) SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation. Basic Res Cardiol 116 25 PMID: 33847835
Do you know of a great paper that uses GS 143 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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