Heclin

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Cat.No. 5433 - Heclin | C17H17NO3 | CAS No. 890605-54-6
Description: HECT E3 ubiquitin ligase inhibitor
Chemical Name: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.

Compound Libraries

Heclin is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 283.32
Formula C17H17NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 890605-54-6
PubChem ID 7464118
InChI Key SPTWXRJNCFIDRQ-ZHACJKMWSA-N
Smiles CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.33 100
ethanol 14.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 283.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.3 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mund et al (2014) Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A. 111 16736 PMID: 25385595


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View Related Products by Product Action

View all Ubiquitin E3 Ligase Inhibitors

Keywords: E6-AP carboxyl terminus HECT E3 ubiquitin ubiquitination inhibitors inhibits inhibts NAMs negative allosteric modulators Ubiquitin E3 Ligases

Citations for Heclin

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Literature in this Area

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for Heclin

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