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Cat.No. 5433 - Heclin | C17H17NO3 | CAS No. 890605-54-6
Description: HECT E3 ubiquitin ligase inhibitor
Chemical Name: N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide
Purity: ≥98% (HPLC)

Biological Activity

HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.

Compound Libraries

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Technical Data

M. Wt 283.32
Formula C17H17NO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 890605-54-6
PubChem ID 7464118
Smiles CC(C1=CC=C(NC(/C=C/C2=CC=C(CC)O2)=O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.33 100
ethanol 14.17 50

Preparing Stock Solutions

The following data is based on the product molecular weight 283.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.53 mL 17.65 mL 35.3 mL
5 mM 0.71 mL 3.53 mL 7.06 mL
10 mM 0.35 mL 1.76 mL 3.53 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

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References are publications that support the biological activity of the product.

Mund et al (2014) Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A. 111 16736 PMID: 25385595

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Keywords: Heclin, Heclin supplier, E6-AP, carboxyl, terminus, HECT, E3, ubiquitin, ubiquitination, inhibitors, inhibits, inhibts, NAMs, negative, allosteric, modulators, Ubiquitin, Ligases, 5433, Tocris Bioscience

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