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HECT E3 ubiquitin ligase inhibitor; inhibits Nedd4, Smurf2 and WWP1 (IC50 values are 6.3, 6.8 and 6.9 μM respectively). Selective for HECT-mediated over RING-mediated ubiquitination.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 283.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.53 mL||17.65 mL||35.3 mL|
|5 mM||0.71 mL||3.53 mL||7.06 mL|
|10 mM||0.35 mL||1.76 mL||3.53 mL|
|50 mM||0.07 mL||0.35 mL||0.71 mL|
References are publications that support the biological activity of the product.
Mund et al (2014) Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc.Natl.Acad.Sci.U.S.A. 111 16736 PMID: 25385595
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Keywords: Heclin, Heclin supplier, E6-AP, carboxyl, terminus, HECT, E3, ubiquitin, ubiquitination, inhibitors, inhibits, inhibts, NAMs, negative, allosteric, modulators, Ubiquitin, Ligases, 5433, Tocris Bioscience
1 Citation for Heclin
Citations are publications that use Tocris products. Selected citations for Heclin include:
Yang et al (2020) Natural cardenolides suppress coronaviral replication by downregulating JAK1 via a Na+/K+-ATPase independent proteolysise Biochem Pharmacol 180 PMID: 32592721
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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