SJ 1008066

Pricing Availability   Qty
Description: MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
Chemical Name: N1-((1H-Indol-5-yl)methyl)-N3-(quinolin-4-yl)propane-1,3-diamine
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for SJ 1008066

SJ 1008066 is a cell permeable inhibitor of testis-restricted melanoma antigen protein MAGE-A11 (IC50 = 0.13 μM). SJ 1008066 binds to the MAGE homology domain (MHD) and disrupts MAGE-A11:PCF11 interaction. SJ1008066 exhibits no effect on MAGE-A3:AMPKα1 or MAGE-F1:MMS19 interactions in TR-FRET and cell lysate pulldown assays.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Compound Libraries for SJ 1008066

SJ 1008066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SJ 1008066

M. Wt 330.44
Formula C21H22N4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2758867-71-7
PubChem ID 162444676
Smiles C12=C(C=CC=C2)C(NCCCNCC3=CC4=C(C=C3)NC=C4)=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SJ 1008066

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.04 100

Preparing Stock Solutions for SJ 1008066

The following data is based on the product molecular weight 330.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.03 mL 15.13 mL 30.26 mL
5 mM 0.61 mL 3.03 mL 6.05 mL
10 mM 0.3 mL 1.51 mL 3.03 mL
50 mM 0.06 mL 0.3 mL 0.61 mL

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References for SJ 1008066

References are publications that support the biological activity of the product.

Yang et al (2020) Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. Nat.Commun. 11 4931 PMID: 33004795

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Keywords: SJ 1008066, SJ 1008066 supplier, SJ1008066, cell, permeable, inhibitors, inhibits, testis-restricted, melanoma, antigen, protein, MAGE-A11, disrupts, MAGE-A11:PCF11, interaction, Ubiquitin, E3, Ligases, 7542, Tocris Bioscience

Citations for SJ 1008066

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