High affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.83 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the products' biological activity.
Wang et al (2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 5 5086 PMID: 25271708
If you know of a relevant reference for SP 141, please let us know.
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Keywords: SP 141, supplier, SP141, High, affinity, MDM2, inhibitors, inhibits, antitumor, antitumour, Mouse, double, minute, 2, homolog, Ubiquitin, E3, Ligases, p53, Ubiquitin, E3, Ligases, Tocris Bioscience
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