SP 141

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Description: High affinity MDM2 inhibitor
Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Purity: ≥98% (HPLC)
Citations (2)
Literature (3)

Biological Activity for SP 141

SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.

Compound Libraries for SP 141

SP 141 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SP 141

M. Wt 324.38
Formula C22H16N2O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1253491-42-7
PubChem ID 59620153
Smiles COC1=CC=C(NC2=C3C=CN=C2C4=CC=CC5=C4C=CC=C5)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SP 141

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.44 100
ethanol 32.44 100

Preparing Stock Solutions for SP 141

The following data is based on the product molecular weight 324.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.41 mL 30.83 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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References for SP 141

References are publications that support the biological activity of the product.

Wang et al (2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 5 5086 PMID: 25271708

If you know of a relevant reference for SP 141, please let us know.

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Keywords: SP 141, SP 141 supplier, SP141, High, affinity, MDM2, inhibitors, inhibits, antitumor, antitumour, Mouse, double, minute, 2, homolog, Ubiquitin, E3, Ligases, p53, 5332, Tocris Bioscience

2 Citations for SP 141

Citations are publications that use Tocris products. Selected citations for SP 141 include:

Weiming et al (2023) MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma. Pathol Oncol Res 29 1610801 PMID: 36741966

Carol et al (2021) MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53. Proc Natl Acad Sci U S A 118 PMID: 34716260

Do you know of a great paper that uses SP 141 from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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