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Biological Activity for SP 141
SP 141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP 141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. SP 141 attenuates growth of breast cancer xenograft tumors. SP 141 impairs liposarcoma growth in vitro and in human xenograft models. SP 141 is cell permeable.
Compound Libraries for SP 141
Technical Data for SP 141
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SP 141
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for SP 141
The following data is based on the product molecular weight 324.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.41 mL||30.83 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References for SP 141
References are publications that support the biological activity of the product.
Wang et al (2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 5 5086 PMID: 25271708
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Keywords: SP 141, SP 141 supplier, SP141, High, affinity, MDM2, inhibitors, inhibits, antitumor, antitumour, Mouse, double, minute, 2, homolog, Ubiquitin, E3, Ligases, p53, 5332, Tocris Bioscience
2 Citations for SP 141
Citations are publications that use Tocris products. Selected citations for SP 141 include:
Weiming et al (2023) MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma. Pathol Oncol Res 29 1610801 PMID: 36741966
Carol et al (2021) MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53. Proc Natl Acad Sci U S A 118 PMID: 34716260
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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