Ligases

Ligases are enzymes which catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class of enzymes, which also includes synthases and carboxylases.

Targets
Literature
Enzyme Data

Literature for Ligases

Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Ligase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MDM2 Human MDM2 NM_006880 Q53XW0
Mouse Mdm2 NM_010786 P23804
Rat Mdm2 NM_001108099 XP_235169
DNA Ligase I Human LIG1 NM_000234 P18858
Mouse Lig1 NM_001083188 P37913
Rat Lig1 NM_030855 Q9JHY8
DNA Ligase III Human LIG3 NM_013975 P49916
Mouse Lig3 NM_010716 P97386
DNA Ligase IV Human LIG4 NM_002312 P49917
Mouse Lig4 NM_176953 Q8BTF7