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Ligases are enzymes which catalyze the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. They belong to the E.C. 6 class of enzymes, which also includes synthases and carboxylases.
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|DNA Ligase I||Human||LIG1||NM_000234||P18858|
|DNA Ligase III||Human||LIG3||NM_013975||P49916|
|DNA Ligase IV||Human||LIG4||NM_002312||P49917|