Tachykinin Receptors

The tachykinin peptides constitute one of the largest peptide families. To date, more than 40 tachykinins have been identified from invertebrate and vertebrate species. In mammals, three prototypical tachykinins have been isolated from neuronal tissue: substance P, neurokinin A and neurokinin B. Recently hemokinin-1 has been isolated from murine blood cells and identified as a new endogenous tachykinin. Three main tachykinin receptor types have been identified: NK1, NK2 and NK3 receptors.

Targets
Literature
Receptor Data

Tachykinin Receptor Target Files

Related Targets

    Literature for Tachykinin Receptors

    GPCR

    GPCR Product Listing

    A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

    • Rhodopsin-like Receptors
    • Secretin-like Receptors
    • Glutamate Receptors
    • Frizzled Receptors
    • GPCR Signaling
    Pain

    Pain Research Product Guide

    A collection of over 250 products for pain research, the guide includes research tools for the study of:

    • Nociception
    • Ion Channels
    • G-Protein-Coupled Receptors
    • Intracellular Signaling
    Peptide Hormone Receptors

    Peptide Hormone Receptors Product Listing

    A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

    • Anterior Pituitary Regulation
    • Blood Pressure Regulation
    • Feeding and Appetite Regulation
    • Glucose Regulation
    • Peptide Hormone Processing
    Peptides Involved in Appetite Modulation

    Peptides Involved in Appetite Modulation Scientific Review

    Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

    Cardiovascular

    Cardiovascular Poster

    Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

    Depression

    Depression Poster

    Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

    Schizophrenia

    Schizophrenia Poster

    Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

    Tachykinin Receptor Data

    Receptor Subtype NK1 NK2 NK3
    Transduction Mechanism Activates Gq/11 Activates Gq/11 Activates Gq/11
    Localization CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei), peripheral tissues Periphery (inflammatory cells and bronchial, gastrointestinal and urinary smooth muscle), limited expression in the CNS CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord), limited expression in the periphery
    Preferred Endogenous Ligand Substance P (1156) > Neurokinin A (1152) > Neurokinin B (1582) Neurokinin A (1152) > Neurokinin B (1582) > Substance P (1156) Neurokinin B (1582) > Neurokinin A (1152) > Substance P (1156)
    Selective Agonists GR 73632 (1669)
    Hemokinin-1 (mouse) (1535)
    [Sar9,Met(O2)11]-Substance P (1178)
    Hemokinin-1 (human) (2576)
    GR 64349 (1668)
    [bAla8]-Neurokinin A(4-10) (1640)
    [Lys5,MeLeu9,Nle10]-NKA(4-10) (3228)
    Senktide (1068)
    Selective Antagonists FK 888 (2400)
    GR 82334 (1670)
    L-732,138 (0868)
    L-733,060 (1145)
    RP 67580 (1635)
    SDZ NKT 343 (2394)
    GR 159897 (1274)
    MDL 29,913 (1194)
    MEN 10376 (1632)
    MEN 10627
    SB 218795 (1376)
    SB 222200 (1393)