[Sar9,Met(O2)11]-Substance P

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Cat.No. 1178 - [Sar9,Met(O2)11]-Substance P | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met-(O2)-NH2 | CAS No. 110880-55-2
Description: Potent, selective NK1 agonist
Datasheet
Citations (1)

Biological Activity

Potent selective NK1 tachykinin receptor agonist.

Technical Data

M. Wt 1393
Formula C64H100N18O15S
Sequence RPKPQQFFXLM

(Modifications: X = Sar, Met-11 = Met(O2), Met-11 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 110880-55-2
PubChem ID 163829
InChI Key OUPXSLGGCPUZJJ-SARDKLJWSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1393. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.72 mL 3.59 mL 7.18 mL
5 mM 0.14 mL 0.72 mL 1.44 mL
10 mM 0.07 mL 0.36 mL 0.72 mL
50 mM 0.01 mL 0.07 mL 0.14 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Cellier et al (1999) Characterisation of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br.J.Pharmacol. 127 717 PMID: 10401563

King et al (1997) Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro. Brain Res. 767 55 PMID: 9365015

Li and Zhao (1998) Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor. Eur.J.Neurosci. 10 1292 PMID: 9749783

Tousignant et al (1990) 125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system. Brain Res. 524 263 PMID: 1705465


If you know of a relevant reference for [Sar9,Met(O2)11]-Substance P, please let us know.

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Keywords: Potent selective NK1 agonists Tachykinin Receptors Neurokinin [Sar9Met(O2)11]-SubstanceP NK1 Receptor Peptide

1 Citation for [Sar9,Met(O2)11]-Substance P

Citations are publications that use Tocris products. Selected citations for [Sar9,Met(O2)11]-Substance P include:

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155


Do you know of a great paper that uses [Sar9,Met(O2)11]-Substance P from Tocris? If so please let us know.

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