[Sar9,Met(O2)11]-Substance P

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Cat.No. 1178 - [Sar9,Met(O2)11]-Substance P | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met-(O2)-NH2 | CAS No. 110880-55-2
Description: Potent and selective NK1 agonist
Datasheet
Citations (2)
Reviews
Literature (6)

Biological Activity

Potent selective NK1 tachykinin receptor agonist.

Technical Data

M. Wt 1393
Formula C64H100N18O15S
Sequence RPKPQQFFXLM

(Modifications: X = Sar, Met-11 = Met(O2), Met-11 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 110880-55-2
PubChem ID 163829
InChI Key OUPXSLGGCPUZJJ-SARDKLJWSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Cellier et al (1999) Characterisation of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br.J.Pharmacol. 127 717 PMID: 10401563

King et al (1997) Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro. Brain Res. 767 55 PMID: 9365015

Li and Zhao (1998) Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor. Eur.J.Neurosci. 10 1292 PMID: 9749783

Tousignant et al (1990) 125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system. Brain Res. 524 263 PMID: 1705465


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Keywords: [Sar9,Met(O2)11]-Substance P, [Sar9,Met(O2)11]-Substance P supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, [Sar9Met(O2)11]-SubstanceP, Receptor, 1178, Tocris Bioscience

2 Citations for [Sar9,Met(O2)11]-Substance P

Citations are publications that use Tocris products. Selected citations for [Sar9,Met(O2)11]-Substance P include:

Khasabov et al (2017) Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla. J Neurophysiol 118 2727 PMID: 28794197

Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155


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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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