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Potent selective NK1 tachykinin receptor agonist.
(Modifications: X = Sar, Met-11 = Met(O2), Met-11 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Cellier et al (1999) Characterisation of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br.J.Pharmacol. 127 717 PMID: 10401563
King et al (1997) Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro. Brain Res. 767 55 PMID: 9365015
Li and Zhao (1998) Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor. Eur.J.Neurosci. 10 1292 PMID: 9749783
Tousignant et al (1990) 125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system. Brain Res. 524 263 PMID: 1705465
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Keywords: [Sar9,Met(O2)11]-Substance P, [Sar9,Met(O2)11]-Substance P supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, [Sar9Met(O2)11]-SubstanceP, Receptor, 1178, Tocris Bioscience
2 Citations for [Sar9,Met(O2)11]-Substance P
Citations are publications that use Tocris products. Selected citations for [Sar9,Met(O2)11]-Substance P include:
Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155
Khasabov et al (2017) Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla. J Neurophysiol 118 2727 PMID: 28794197
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.