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NK2 tachykinin receptor selective antagonist.
(Modifications: Leu-5 - Leu-6 = Leu-CH2N(CH3)-Leu, Cyclized)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 0.50 mg/ml in acetonitrile / water|
References are publications that support the biological activity of the product.
Black et al (1992) Tachykinin receptors in rabbit airways - characterization by functional, autoradiographic and binding studies. Br.J.Pharmacol. 107 429 PMID: 1384914
Maggi et al (1993) MEN 10,573 and MEN 10,612, novel cyclic pseudopeptides which are potent tachykinin NK-2 receptor antagonists. Regul.Pept. 47 151 PMID: 8234901
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Keywords: MDL 29,913, MDL 29,913 supplier, Selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MDL29913, Receptor, 1194, Tocris Bioscience
1 Citation for MDL 29,913
Citations are publications that use Tocris products. Selected citations for MDL 29,913 include:
Wease and Davies (2005) Substance P selectively decreases paired pulse depression in the rat hippocampal slice. BMC Neurosci 6 66 PMID: 16305744
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.