MDL 29,913

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Cat.No. 1194 - MDL 29,913 | Cyclo[Gln-Trp-Phe-Gly-Leu-CH2N(CH3)-Leu] | CAS No. 135721-56-1
Description: Selective NK2 antagonist
Datasheet
Citations
Literature

Biological Activity

NK2 tachykinin receptor selective antagonist.

Technical Data

M. Wt 745
Formula C40H56N8O6
Sequence QWFGLL

(Modifications: Leu-5 - Leu-6 = Leu-CH2N(CH3)-Leu, Cyclized)

Storage Desiccate at -20°C
CAS Number 135721-56-1
PubChem ID 90479769
InChI Key HTXNHRVBQSWFDI-QEQIFPIFSA-N
Smiles CC(C)C[C@@H]1NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 0.50 mg/ml in acetonitrile / water

Preparing Stock Solutions

The following data is based on the product molecular weight 745. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.34 mL 6.71 mL 13.42 mL
5 mM 0.27 mL 1.34 mL 2.68 mL
10 mM 0.13 mL 0.67 mL 1.34 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Black et al (1992) Tachykinin receptors in rabbit airways - characterization by functional, autoradiographic and binding studies. Br.J.Pharmacol. 107 429 PMID: 1384914

Maggi et al (1993) MEN 10,573 and MEN 10,612, novel cyclic pseudopeptides which are potent tachykinin NK-2 receptor antagonists. Regul.Pept. 47 151 PMID: 8234901


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Keywords: MDL 29,913, supplier, Selective, NK2, antagonists, Tachykinin, Receptors, Neurokinin, MDL29913, NK2, Receptor, NK2, Receptor, Tocris Bioscience

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