Potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). Active in vivo.
Sold for research purposes under agreement from GlaxoSmithKline
(Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 766.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.31 mL||6.53 mL||13.05 mL|
|5 mM||0.26 mL||1.31 mL||2.61 mL|
|10 mM||0.13 mL||0.65 mL||1.31 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
References are publications that support the biological activity of the product.
Hall and Morton (1991) Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation. Ann.N.Y.Acad.Sci. 632 404 PMID: 1719888
Meini et al (1995) GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder. Neuropeptides 28 99 PMID: 7538205
Sakurada et al (1999) Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides 20 301 PMID: 10422886
If you know of a relevant reference for GR 73632, please let us know.
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Keywords: GR 73632, GR 73632 supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, GR73632, GlaxoSmithKline, GSK, Receptor, 1669, Tocris Bioscience
5 Citations for GR 73632
Citations are publications that use Tocris products. Selected citations for GR 73632 include:
Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576 PMID: 25490143
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241
León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Endocrinology 6 19206 PMID: 26755241
Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Mol Psychiatry 156 627 PMID: 25422875
Liu et al (2013) TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J 27 3549 PMID: 23722916
Do you know of a great paper that uses GR 73632 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.