[bAla8]-Neurokinin A(4-10)

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Cat.No. 1640 - [bAla8]-Neurokinin A(4-10) | Asp-Ser-Phe-Val-β-Ala-Leu-Met-NH2 | CAS No. 122063-01-8
Description: NK2 agonist
Alternative Names: MEN 10210

Biological Activity

NK2 receptor agonist (pD2 = 6.91). Produces bladder contraction and bronchospasm in guinea pigs in vivo.

Technical Data

M. Wt 780.93
Formula C35H56N8O10S
Sequence DSFVALM

(Modifications: Ala-5 = β-Ala, Met-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 122063-01-8
PubChem ID 9987795
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in 5% NH4OH / water

Preparing Stock Solutions

The following data is based on the product molecular weight 780.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.28 mL 6.4 mL 12.81 mL
5 mM 0.26 mL 1.28 mL 2.56 mL
10 mM 0.13 mL 0.64 mL 1.28 mL
50 mM 0.03 mL 0.13 mL 0.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Carini et al (2001) Tachykinin NK2 receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study. Br.J.Pharmacol. 133 1107 PMID: 11487522

Maggi et al (1990) In vivo pharmacology of [βAla8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur.J.Pharmacol. 177 81 PMID: 2160369

Rovero et al (1989) A potent and selective agonist for NK-2 tachykinin receptor. Peptides 10 593 PMID: 2550911

If you know of a relevant reference for [bAla8]-Neurokinin A(4-10), please let us know.

View Related Products by Target

Keywords: NK2 agonists Tachykinin Receptors Neurokinin MEN10210 MEN 10210 NK2 Receptor Peptide

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