[bAla8]-Neurokinin A(4-10)

Discontinued Product

[bAla8]-Neurokinin A(4-10) (Cat. No. 1640) has been withdrawn from sale for commercial reasons.
Description: NK2 agonist
Alternative Names: MEN 10210
Citations (1)
Literature (2)

Biological Activity for [bAla8]-Neurokinin A(4-10)

[bAla8]-Neurokinin A(4-10) is a NK2 receptor agonist (pD2 = 6.91). Produces bladder contraction and bronchospasm in guinea pigs in vivo.

Technical Data for [bAla8]-Neurokinin A(4-10)

M. Wt 780.93
Formula C35H56N8O10S
Sequence DSFVALM

(Modifications: Ala-5 = β-Ala, Met-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 122063-01-8
PubChem ID 9987795
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NCCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for [bAla8]-Neurokinin A(4-10)

Certificate of Analysis / Product Datasheet
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References for [bAla8]-Neurokinin A(4-10)

References are publications that support the biological activity of the product.

Carini et al (2001) Tachykinin NK2 receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study. Br.J.Pharmacol. 133 1107 PMID: 11487522

Maggi et al (1990) In vivo pharmacology of [βAla8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur.J.Pharmacol. 177 81 PMID: 2160369

Rovero et al (1989) A potent and selective agonist for NK-2 tachykinin receptor. Peptides 10 593 PMID: 2550911

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Keywords: [bAla8]-Neurokinin A(4-10), [bAla8]-Neurokinin A(4-10) supplier, NK2, agonists, Tachykinin, Receptors, Neurokinin, MEN10210, MEN, 10210, Receptor, 1640, Tocris Bioscience

1 Citation for [bAla8]-Neurokinin A(4-10)

Citations are publications that use Tocris products. Selected citations for [bAla8]-Neurokinin A(4-10) include:

Cavalcanti-de-Albuquerque et al (2019) Regulation of substrate utilization and adiposity by Agrp neurons. Nat Commun 10 311 PMID: 30659173

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Depression Poster

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