NK2 receptor agonist (pD2 = 6.91). Produces bladder contraction and bronchospasm in guinea pigs in vivo.
(Modifications: Ala-5 = β-Ala, Met-7 = C-terminal amide)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in 5% NH4OH / water|
Preparing Stock Solutions
The following data is based on the product molecular weight 780.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.28 mL||6.4 mL||12.81 mL|
|5 mM||0.26 mL||1.28 mL||2.56 mL|
|10 mM||0.13 mL||0.64 mL||1.28 mL|
|50 mM||0.03 mL||0.13 mL||0.26 mL|
References are publications that support the products' biological activity.
Carini et al (2001) Tachykinin NK2 receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study. Br.J.Pharmacol. 133 1107 PMID: 11487522
Maggi et al (1990) In vivo pharmacology of [βAla8]neurokinin A-(4-10), a selective NK-2 tachykinin receptor agonist. Eur.J.Pharmacol. 177 81 PMID: 2160369
Rovero et al (1989) A potent and selective agonist for NK-2 tachykinin receptor. Peptides 10 593 PMID: 2550911
If you know of a relevant reference for [bAla8]-Neurokinin A(4-10), please let us know.
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Keywords: [bAla8]-Neurokinin A(4-10), supplier, NK2, agonists, Tachykinin, Receptors, Neurokinin, MEN10210, MEN, 10210, NK2, Receptor, NK2, Receptor, Tocris Bioscience
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Literature in this Area
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.