GR 64349

Pricing Availability Delivery Time Qty
Cat.No. 1668 - GR 64349 | Lys-Asp-Ser-Phe-Val-Gly-R-γ-lactam-Leu-Met-NH2 | CAS No. 137593-52-3
Description: Potent, selective NK2 agonist
Datasheet
Citations (3)
Literature

Biological Activity

Potent and selective tachykinin NK2 receptor agonist (EC50 = 3.7 nM in rat colon). Displays > 1000- and > 300-fold selectivity over NK1 and NK3 receptors respectively. Active in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 921.12
Formula C42H68N10O11S
Sequence KDSFVGLM

(Modifications: Leu-7 = R-γ-lactam-Leu, Met-8 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 137593-52-3
PubChem ID 5311135
InChI Key HVUNRXRFMQDMBO-BPZYSUIOSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)NC1CCN([C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 921.12. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.09 mL 5.43 mL 10.86 mL
5 mM 0.22 mL 1.09 mL 2.17 mL
10 mM 0.11 mL 0.54 mL 1.09 mL
50 mM 0.02 mL 0.11 mL 0.22 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chang et al (2000) Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J.Pharmacol.Exp.Ther. 294 147 PMID: 10871306

Chizh et al (1995) Endogenous modulation of excitatory amino acid responsiveness by tachykinin NK1 and NK2 receptors in the rat spinal cord. Br.J.Pharmacol. 115 1013 PMID: 7582497

Deal et al (1992) Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J.Med.Chem. 35 4195 PMID: 1331460


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Keywords: GR 64349, supplier, Potent, selective, NK2, agonists, Tachykinin, Receptors, Neurokinin, GR64349, GlaxoSmithKline, GSK, NK2, Receptor, Tocris Bioscience

3 Citations for GR 64349

Citations are publications that use Tocris products. Selected citations for GR 64349 include:

León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241

Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576 PMID: 25490143

Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Sci Rep 156 627 PMID: 25422875


Do you know of a great paper that uses GR 64349 from Tocris? If so please let us know.

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