MEN 10376

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Cat.No. 1632 - MEN 10376 | Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2 | CAS No. 135306-85-3
Description: Potent, selective NK2 antagonist
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.

Technical Data

M. Wt 1081.24
Formula C57H68N12O10
Sequence DYWVWWK

(Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 135306-85-3
PubChem ID 90479818
InChI Key QQHOFZNACVKNHK-JRPYWGABSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Product Datasheets

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References

References are publications that support the biological activity of the product.

Bartho et al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors. Br.J.Pharmacol. 105 805 PMID: 1380373

Maggi et al (1991) In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172 PMID: 1710662

Subramanian et al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line. Biochem.Biophys.Res.Commun. 200 1512 PMID: 8185607


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