MEN 10376

Pricing Availability Delivery Time Qty
Cat.No. 1632 - MEN 10376 | Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Lys-NH2 | CAS No. 135306-85-3
Description: Potent, selective NK2 antagonist
Datasheet
Citations

Biological Activity

Potent and selective NK2 receptor antagonist (pA2 = 8.08, rabbit pulmonary artery). Displays > 250-fold selectivity over NK1 (pA2 = 5.66, guinea pig ileum) and NK3 (Ki > 10 mM, guinea pig brain). Active in vivo.

Technical Data

M. Wt 1081.24
Formula C57H68N12O10
Sequence DYWVWWK

(Modifications: Trp-3, Trp-5, Trp-6 = D-Trp, Lys-7 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 135306-85-3
PubChem ID 90479818
InChI Key QQHOFZNACVKNHK-JRPYWGABSA-N
Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1081.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.92 mL 4.62 mL 9.25 mL
5 mM 0.18 mL 0.92 mL 1.85 mL
10 mM 0.09 mL 0.46 mL 0.92 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bartho et al (1992) Tachykininergic transmission to the circular muscle of the guinea-pig ileum: evidence for the involvement of NK2 receptors. Br.J.Pharmacol. 105 805 PMID: 1380373

Maggi et al (1991) In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376. J.Pharmacol.Exp.Ther. 257 1172 PMID: 1710662

Subramanian et al (1994) Pharmacological evidence of tachykinin-induced intracellular calcium rise in a human NK2 receptor transfected cell line. Biochem.Biophys.Res.Commun. 200 1512 PMID: 8185607


If you know of a relevant reference for MEN 10376, please let us know.

View Related Products by Target

Keywords: Potent selective NK2 antagonists Tachykinin Receptors Neurokinin MEN10376 NK2 Receptor Peptide

Citations for MEN 10376

Citations are publications that use Tocris products.

Currently there are no citations for MEN 10376. Do you know of a great paper that uses MEN 10376 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Pathways for MEN 10376

Protocols

TODO: Add Protocols